Synthesis and Biological Activity of 1-Hydroxyethyl- and 1-(4-Hydroxyphenyl)-5-Aryl-4-Aroyl-3-Pyrrolin-2-Ones

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Resumo

New 1-(2-hydroxyethyl)- and 1-(4-hydroxyphenyl)-5-aryl-4-aroyl-3-hydroxy-3-pyrroline-2-ones were synthesized by the reaction of methyl esters of aroylpyruvic acids, aromatic aldehydes and ethanolamine (p-aminophenol). The antimicrobial and antinociceptive activity of the obtained compounds was studied.

Sobre autores

V. Gein

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

V. Batov

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

D. Rubtsov

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

N. Nosova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation; Perm State Medical University named after Academician E. A. Wagner of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia; Perm, 614990 Russia

I. Mokrushin

Perm State National Research University

Email: geinvl48@mail.ru
Perm, 614068 Russia

L. Gein

Perm State Medical University named after Academician E. A. Wagner of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

A. Gagarina

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

V. Novikova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

R. Makhmudov

Perm State National Research University; Federal Scientific Center for Medical and Preventive Technologies for Health Risk Management

Autor responsável pela correspondência
Email: geinvl48@mail.ru
Perm, 614068 Russia; Perm, 614045 Russia

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