The role of photobiomodulation therapy in reducing stress-induced changes in the hippocampus of rats during septoplasty modeling

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The aim of the study. To study the effect of photobiomodulation therapy (PBMT) on the amount of p53 in neurons of the pyramidal layer of the hippocampus after modeling septoplasty in rats. Materials and methods. Septoplasty was modeled in 48 Wistar rats. In the postoperative period, PBMT was administered to 24 rats in the early postoperative period for 2 to 6 days. Histological sections of the hippocampus were studied to determine p53-positive neurons on days 2, 4 and 6 after surgery in rats of both groups. Results. Compared with the control group (n=5 rats), in both experimental groups there was an increase in the number of p53-positive neurons in the hippocampus, however, in the group where PBMT was performed in the early postoperative period after modeling septoplasty, the number of such neurons was lower, and in some subfields of the hippocampus on day 6 it even corresponded to the control group. Conclusion. The use of PBMT in the early postoperative period after modeling septoplasty helps to reduce stress-induced expression of the p53 protein in the pyramidal layer of the hippocampus in rats.

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Sobre autores

V. Kotov

P. Lumumba Peoples’ Friendship University of Russia

Autor responsável pela correspondência
Email: fnkc.vladislav@gmail.com
Rússia, Moscow

I. Kastyro

P. Lumumba Peoples’ Friendship University of Russia

Email: fnkc.vladislav@gmail.com
Rússia, Moscow

I. Ganshin

P. Lumumba Peoples’ Friendship University of Russia

Email: fnkc.vladislav@gmail.com
Rússia, Moscow

V. Popadyuk

P. Lumumba Peoples’ Friendship University of Russia

Email: fnkc.vladislav@gmail.com
Rússia, Moscow

S. Dragunova

P. Lumumba Peoples’ Friendship University of Russia

Email: fnkc.vladislav@gmail.com
Rússia, Moscow

O. Khodorovich

P. Lumumba Peoples’ Friendship University of Russia

Email: fnkc.vladislav@gmail.com
Rússia, Moscow

А. Kartasheva

P. Lumumba Peoples’ Friendship University of Russia

Email: fnkc.vladislav@gmail.com
Rússia, Moscow

M. Barannik

P. Lumumba Peoples’ Friendship University of Russia

Email: fnkc.vladislav@gmail.com
Rússia, Moscow

P. Sarygin

P. Lumumba Peoples’ Friendship University of Russia

Email: fnkc.vladislav@gmail.com
Rússia, Moscow

Bibliografia

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2. Fig. 1. Dynamics of changes in p53-positive neurons after modeling septoplasty and the use of FBMT in the subfield (a) CA1, (b) CA2, (c) CA3 of the hippocampus. * - differences between the terms in the experimental groups (p < 0.001); † - differences between the terms in the experimental groups (p < 0.01); ‡ - differences between the terms in the experimental groups (p < 0.05); ○ - differences between the experimental groups at different terms (p < 0.001); • - differences between the experimental groups at different terms (p < 0.01); ◊ - differences between the experimental groups at different terms (p < 0.05); ∆ - differences between the intact (1st group) and experimental groups (p < 0.001); □ – differences between the intact (1st group) and experimental groups (p < 0.01); ⌂ – differences between the intact (1st group) and experimental groups (p < 0.05).

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Presented by Academician of the RAS I.V. Reshetov


Declaração de direitos autorais © Russian Academy of Sciences, 2025