The Functions and Application Prospects of Hepatocyte Growth Factor in Reproduction


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Аннотация

Hepatocyte growth factor (HGF) is expressed in multiple systems and mediates a variety of biological activities, such as mitosis, motility, and morphogenesis. A growing number of studies have revealed the expression patterns and functions of HGF in ovarian and testicular physiology from the prenatal to the adult stage. HGF regulates folliculogenesis and steroidogenesis by modulating the functions of theca cells and granulosa cells in the ovary. It also mediates somatic cell proliferation and steroidogenesis, thereby affecting spermatogenesis in males. In addition to its physiological effects on the reproductive system, HGF has shown advantages in preclinical studies over recent years for the treatment of male and female infertility, particularly in women with premature ovarian insufficiency. This review aims to summarize the pleiotropic functions of HGF in the reproductive system and to provide prospects for its clinical application.

Об авторах

Xin Mi

Institute of Women, Children and Reproductive Health, Shandong University

Email: info@benthamscience.net

Caiyi Chen

Institute of Women, Children and Reproductive Health,, Shandong University

Email: info@benthamscience.net

Chen Feng

Institute of Women, Children and Reproductive Health, Shandong University

Email: info@benthamscience.net

Yingying Qin

Institute of Women, Children and Reproductive Health, S, Shandong University

Email: info@benthamscience.net

Zi-Jiang Chen

Institute of Women, Children and Reproductive Health, Shandong University

Email: info@benthamscience.net

Yajuan Yang

Institute of Women, Children and Reproductive Health,, Shandong University

Автор, ответственный за переписку.
Email: info@benthamscience.net

Shidou Zhao

Institute of Women, Children and Reproductive Health,, Shandong University

Автор, ответственный за переписку.
Email: info@benthamscience.net

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