ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application


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Abstract

ARL15 is a member of the RAS superfamily of small GTPases and is associated with several metabolic traits, including increased risk of diabetes, rheumatoid arthritis and lipid metabolism disorders. The ARL15 gene encodes for an uncharacterized small GTP binding protein. Its precise role in human physiology remains unknown, but several genetic association studies have recognized different variants in this gene to be statistically associated with numerous traits and complex diseases. Here, we provided the unique features of ARL15 small G protein, its association with varied metabolic and lifestyle diseases, its function in vesicular and lipid trafficking, and its binding partners. We outlined this protein as a promising and emerging therapeutic target to combat metabolic disorders like cardiovascular diseases, diabetes and rheumatoid arthritis. The review provides a comprehensive description of the current advancements in ARL15 research with a perspective that focused research will position this small GTPase as a viable target for the treatment of rheumatoid arthritis.

About the authors

Manisha Saini

Department of Biochemistry, University of Delhi South Campus

Email: info@benthamscience.net

Varnita Anand

Department of Biochemistry, University of Delhi South Campus

Email: info@benthamscience.net

Aditya Sharma

Department of Genetics,, University of Delhi South Campus

Email: info@benthamscience.net

Anuj Pandey

Department of Genetics, University of Delhi South Campus

Email: info@benthamscience.net

Bittianda Thelma

Department of Genetics, University of Delhi South Campus

Email: info@benthamscience.net

Suman Kundu

Department of Biochemistry, University of Delhi South Campus

Author for correspondence.
Email: info@benthamscience.net

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