The analysis of survival and life potential loss in workers diagnosed with acute radiation sickness following a radiation accident

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Abstract

Evaluation of ionizing radiation impact on life expectancy rates in humans is one of the topical problems of the radiation medicine. The present study aimed to analyze survival rates and the life potential loss in workers of the Mayak PA after the acute radiation sickness due to radiation accidents and in radiation accident participants who had not suffered from the acute radiation sickness. The analysis considered 64 workers of the Mayak PA (54 males and 10 females), and it was performed using the STATISTICA 10 software. We evaluated survival rates prior to and after the main disease that had caused death, percentages of individuals who had not survived to 40, 60, 80 and 80+ years, and total, partial and single (weighted means) life potential loss and the index of the life potential loss. The analysis revealed that workers with severe and extremely severe acute radiation sickness demonstrated deteriorated survival rates and the increased life potential loss compared either to workers with moderate and modest acute radiation sickness or to radiation accident participants. The cause for such estimates in workers with severe and extreme severe sickness was the extreme course of the sickness. In cases of the severe sickness, the shortening of life duration was caused mainly by the preliminary death from malignant neoplasms and the acute radiation sickness. We observed the linear regression association of survival rates and life potential loss with 1 Ln of radiation dose. The relative risk of deterioration of the survival rate and the increase of the life potential loss was considerably higher (3.64-52.0 times, p < 0.05–0.001) in workers with the severe and extreme severe acute radiation sickness acutely exposed at higher doses (above 5 or 120 Gy) compared to other workers.

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About the authors

Vitaliy I. Telnov

Southern Urals Biophysics Institute affiliated to the Federal Medical Biological Agency

Author for correspondence.
Email: tvi@subi.su
ORCID iD: 0000-0003-3509-5372
Russian Federation, Ozyorsk

Tamara V. Azizova

Southern Urals Biophysics Institute affiliated to the Federal Medical Biological Agency

Email: clinic@subi.su
ORCID iD: 0000-0001-6954-2674
Russian Federation, Ozyorsk

Mariya B. Moseeva

Southern Urals Biophysics Institute affiliated to the Federal Medical Biological Agency

Email: moseeva@subi.su
ORCID iD: 0000-0003-3741-6600
Russian Federation, Ozyorsk

Mariya V. Bannikova

Southern Urals Biophysics Institute affiliated to the Federal Medical Biological Agency

Email: bannikova@subi.su
ORCID iD: 0000-0002-2755-6282
Russian Federation, Ozyorsk

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2. Fig. 1. Average absorbed doses of acute radiation exposure in workers with ARS (various levels of severity) and in accident participants.

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3. Fig 2. Causes of death (structure) in workers with ARS (various severity levels) and in radiation accident participants (the description is provided within the text).

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