Cationic Complexes of Magnesium with Phenanthroline. Synthesis, Structural Features and Antibacterial Activity

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Abstract

The interaction of magnesium oxide/magnesium pivalate with aromatic heterocyclic acids (3-indolecarboxylic (Hind); 2-thiophenecarboxylic (Htph)) and 1,10-phenanthroline (phen) led to the formation of cationic complexes [Mg(phen)(ind)(H2O)3]+ind−·2phen·1.5H2O (I) and [Mg(phen)(H2O)4]32+·6thp−·2phen (II), the structure of which was established by direct X-ray diffraction analysis (CCDC Nos. 2422043 (I) and 2422042 (II)). According to X-ray data, the complexing agent in compounds I and II is in a distorted octahedral environment {MgN2O4} with the coordination number of the magnesium atom equal to 6. In the crystal packing of I, stacking interactions are observed between the aromatic phen cycles, forming parallel stacks held together by hydrogen bonds. Outer-sphere tph− in II form strong hydrogen bonds with the coordinated water molecules, forming an 1D hydrogen-bonded framework. Antibacterial activity against a non-pathogenic strain of M. smegmatis and two strains — Lactobacterium brevis and Lactobacillus fermentum was determined for I and II. Antiproliferative activity of I was determined against cancer lines of human ovarian adenocarcinoma (SKOV3), breast adenocarcinoma (MCF7) and glioblastoma (A172).

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About the authors

S. M. Potylitsyna

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Lomonosov Moscow State University

Email: irinalu05@rambler.ru
Russian Federation, Moscow; Moscow

K. A. Koshenskova

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: irinalu05@rambler.ru
Russian Federation, Moscow

M. E. Nikiforova

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: irinalu05@rambler.ru
Russian Federation, Moscow

L. S. Razvorotneva

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; National Research University Higher School of Economics

Email: irinalu05@rambler.ru
Russian Federation, Moscow; Moscow

F. M. Dolgushin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: irinalu05@rambler.ru
Russian Federation, Moscow

O. B. Bekker

Vavilov Institute of General Genetics, Russian Academy of Sciences

Email: irinalu05@rambler.ru
Russian Federation, Moscow

A. S. Zaeva

Amur State Medical Academy of the Ministry of Healthcare of the Russian Federation

Email: irinalu05@rambler.ru
Russian Federation, Blagoveschensk

M. A. Kiskin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: irinalu05@rambler.ru
Russian Federation, Moscow

I. L. Eremenko

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Email: irinalu05@rambler.ru
Russian Federation, Moscow; Moscow

I. A. Lutsenko

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Author for correspondence.
Email: irinalu05@rambler.ru
Russian Federation, Moscow

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Supplementary files

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2. Scheme 1.

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3. Fig. 1. Independent part of the unit cell in structure I (thermal ellipsoids of atoms are shown with a probability of 50%).

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4. Fig. 2. Stacking interactions in structure I.

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5. Fig. 3. Fragment of crystal packing II (thermal ellipsoids of atoms are given with a probability of 50%).

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6. Fig. 4. Stacking interactions in structure II.

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