Non-Classical Cannabinoid Receptors: Modern Concepts of Signal Transmission Functions and Mechanisms

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The objective of this review is to summarize current understanding of non-classical cannabinoid receptors, their signaling mechanisms, and roles in physiological and pathological processes. Non-classical receptors (GPR55, GPR18, GPR119, etc.) demonstrate tissue-specific expression, interaction with multiple G proteins, and ligand-dependent activation of signaling pathways. GPR55 is involved in the regulation of pain, angiogenesis, and oncogenesis; GPR18 modulates inflammation and metabolism; GPR119 is promising for diabetes therapy. Their ability to heterodimerize has been identified, which complicates their pharmacological profile. Non-classical cannabinoid receptors represent promising targets for the treatment of socially significant diseases (cancer, diabetes, neurodegeneration). However, their context-dependent activity requires in-depth study to develop selective drugs.

About the authors

M. G Akimov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences

Email: akimovmike@gmail.com
Moscow, Russia

N. M Gretskaya

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences

Moscow, Russia

V. V Bezuglov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences; National Research Nuclear University MEPhI

Moscow, Russia; Moscow, Russia

References

  1. Matei D., Trofin D., Iordan D.A., Onu I., Condurache I., Ionite C., Buculei I. // Int. J. Mol. Sci. 2023. V. 24. P. 1989. https://doi.org/10.3390/ijms24031989
  2. Simankowicz P., Stępniewska J. // J. Clin. Med. 2025. V. 14. P. 2851. https://doi.org/10.3390/jcm14082851
  3. Starowicz K., Nigam S., Di Marzo V. // Pharmacol. Ther. 2007. V. 114. P. 13–33. https://doi.org/10.1016/j.pharmthera.2007.01.005
  4. Chianese R., Ciaramella V., Scarpa D., Fasano S., Pierantoni R., Meccariello R. // Int. J. Endocrinol. 2013. V. 2013. P. 904748. https://doi.org/10.1155/2013/904748.
  5. Woodward D.F., Liang Y., Krauss A.H. // Br. J. Pharmacol. 2008. V. 153. P. 410–419. https://doi.org/10.1016/j.prostaglandins.2017.03.003
  6. Sang N., Zhang J., Chen C. // J. Neurochem. 2007. V. 102. P. 1966–1977. https://doi.org/10.1111/j.1471-4159.2007.04668.x
  7. Sugiura T., Kobayashi Y., Oka S., Waku K. // Prostaglandins Leukot. Essent. Fatty Acids 2002. V. 66. P. 173–192. https://doi.org/10.1054/plef.2001.0356
  8. Scheyer A., Yasmin F., Naskar S., Patel S. // Neuropsychopharmacology. 2023. V. 48. P. 37–53. https://doi.org/10.1038/s41386-022-01438-7
  9. Balezina O.P., Tarasova E.O., Bogacheva P.O. // Biochemistry (Moscow) 2024. V. 89. P. 1759– 1778. https://doi.org/10.1134/s0006297924100080
  10. Bobrov M.Yu., Akimov M.G., Gretskaya N.M., Serkov I.V., Barskov I.V., Khaspekov L.G., Bezuglov V.V. // Endocannabinoids: Chemical Structure, Role in Physiological Processes and Therapeutic Effects. Nova Science Publishers, 2015.
  11. Brown A.J. // Br. J. Pharmacol. 2007. V. 152. P. 567– 575. https://doi.org/10.1038/sj.bjp.0707481
  12. Irving A., Abdulrazzaq G., Chan S.L.F., Penman J., Harvey J., Alexander S.P.H. // Adv. Pharmacol. 2017. V. 80. P. 223–247. https://doi.org/10.1016/bs.apha.2017.04.004
  13. Ehrlich B., Patel M., Zheng X., Glass M. // Canonical Cannabinoid Receptors. In: Current Topics in Behavioral Neurosciences. Springer, Berlin, Heidelberg. 2024. https://doi.org/10.1007/7854_2024_556
  14. Shen S.-Y., Wu C., Yang Z.-Q., Wang K.-X., Shao Z.-H., Yan W. // Acta Pharmacol. Sin. 2025. V. 46. P. 1495– 1510. https://doi.org/10.1038/s41401-024-01472-9
  15. An D., Peigneur S., Hendrickx L.A., Tytgat J. // Int. J. Mol. Sci. 2020. V. 21. P. 5064. https://doi.org/10.3390/ijms21145064
  16. Moreno E., Cavic M., Krivokuca A., Canela E.I. // Cancers 2020. V. 12. P. 3275. https://doi.org/10.3390/cancers12113275
  17. Hampson A.J., Grimaldi M., Axelrod J., Wink D. // Proc. Natl. Acad. Sci. USA. 1998. V. 95. P. 8268–8273. https://doi.org/10.1073/pnas.95.14.8268
  18. Yin H., Chu A., Li W., Wang B., Shelton F., Otero F., Nguyen D.G., Caldwell J.S., Chen Y.A. // J. Biol. Chem. 2009. V. 284. P. 12328–12338. https://doi.org/10.1074/jbc.m806516200
  19. Bouma J., Soethoudt M., van Gils N., Xia L., van der Stelt M., Heitman L.H. // Methods Mol. Biol. 2023. V. 2576. P. 189–199. https://doi.org/10.1007/978-1-0716-2728-0_15
  20. Haider R.S., Godbole A., Hoffmann C. // Curr. Opin. Cell Biol. 2019. V. 57. P. 16–24. https://doi.org/10.1016/j.ceb.2018.10.005
  21. Janicot R., Garcia-Marcos M. // Mol. Pharmacol. 2024. V. 106. P. 129–144. https://doi.org/10.1124/molpharm.124.000949
  22. Pearce A., Redfern-Nichols T., Wills E., Rosa M., Manulak I., Sisk C., Huang X., Atakpa-Adaji P., Prole D.L., Ladds G. // J. Cell Sci. 2025. V. 138. P. jcs263434. https://doi.org/10.1242/jcs.263434
  23. Jean-Charles P.-Y., Kaur S., Shenoy S.K. // J. Cardiovasc. Pharmacol. 2017. V. 70. P. 142–158. https://doi.org/10.1097/fjc.0000000000000482
  24. Ahn S., Shenoy S.K., Luttrell L.M., Lefkowitz R.J. // Cell 2020. V. 182. P. 1362–1362.e1. https://doi.org/10.1016/j.cell.2020.07.034
  25. Howlett A.C., Abood M.E. // Adv. Pharmacol. 2017. V. 80. P. 169–206. https://doi.org/10.1016/bs.apha.2017.03.007
  26. Pertwee R.G., Howlett A.C., Abood M.E., Alexander S.P.H., Di Marzo V., Elphick M.R., Greasley P.J., Hansen H.S., Kunos G., Mackie K., Mechoulam R., Ross R.A. // Pharmacol. Rev. 2010. V. 62. P. 588– 631. https://doi.org/10.1124/pr.110.003004
  27. An D., Peigneur S., Hendrickx L.A., Tytgat J. // Int. J. Mol. Sci. 2020. V. 21. P. 5064. https://doi.org/10.3390/ijms21145064
  28. Grabiec U., Dehghani F. // Cannabis Cannabinoid Res. 2017. V. 2. P. 183–196. https://doi.org/10.1089/can.2017.0015
  29. Järbe T.U.C., Lamb R.J., Liu Q., Makriyannis A. // Psychopharmacology. 2006. V. 188. P. 315–323. https://doi.org/10.1007/s00213-006-0517-x
  30. Coronado-Álvarez A., Romero-Cordero K., Macías-Triana L., Tatum-Kuri A., Vera-Barrón A., Budde H., Machado S., Yamamoto T., Imperatori C., Murillo- Rodríguez E. // Prog. Neuropsychopharmacol. Biol. Psychiatry. 2021. V. 110. P. 110301. https://doi.org/10.1016/j.pnpbp.2021.110301
  31. Lauckner J.E., Hille B., Mackie K. // Proc. Natl. Acad. Sci. USA. 2005. V. 102. P. 19144–19149. https://doi.org/10.1073/pnas.0509588102
  32. Glass M., Felder C.C. // J. Neurosci. 1997. V. 17. P. 5327–5333. https://doi.org/10.1523/jneurosci.17-14-05327.1997
  33. Mechoulam R., Ben-Shabat S., Hanus L., Ligumsky M., Kaminski N.E., Schatz A.R., Gopher A., Almog S., Martin B.R., Compton D.R., Pertwee R.G., Griffin G., Bayewitch M., Barg J., Vogel Z. // Biochem. Pharmacol. 1995. V. 50. P. 83–90. https://doi.org/10.1016/0006-2952(95)00109-d
  34. Robinson R.H., Meissler J.J., Fan X., Yu D., Adler M.W., Eisenstein T.K. // J. Neuroimmune Pharmacol. 2015. V. 10. P. 318–332. https://doi.org/10.1007/s11481-015-9611-3
  35. Mnpotra J.S., Qiao Z., Cai J., Lynch D.L., Grossfield A., Leioatts N., Hurst D.P., Pitman M.C., Song Z.-H., Reggio P.H. // J. Biol. Chem. 2014. V. 289. P. 20259–20272. https://doi.org/10.1074/jbc.m113.539916
  36. Oka S., Nakajima K., Yamashita A., Kishimoto S., Sugiura T. // Biochem. Biophys. Res. Commun. 2007. V. 362. P. 928–934. https://doi.org/10.1016/j.bbrc.2007.08.078
  37. Lauckner J.E., Jensen J.B., Chen H.-Y., Lu H.-C., Hille B., Mackie K. // Proc. Natl. Acad. Sci. USA. 2008. V. 105. P. 2699–2704. https://doi.org/10.1073/pnas.0711278105
  38. Akimov M.G., Gamisonia A.M., Dudina P.V., Gretskaya N.M., Gaydaryova A.A., Kuznetsov A.S., Zinchenko G.N., Bezuglov V.V. // Int. J. Mol. Sci. 2021. V. 22. P. 622. https://doi.org/10.3390/ijms22020622
  39. McHugh D., Hu S.S., Rimmerman N., Juknat A., Vogel Z., Walker J.M., Bradshaw H.B. // BMC Neurosci. 2010. V. 11. P. 44. https://doi.org/10.1186/1471-2202-11-44
  40. Zhang X., Maor Y., Wang J., Kunos G., Groopman J. // Br. J. Pharmacol. 2010. V. 160. P. 1583–1594. https://doi.org/10.1111/j.1476-5381.2010.00841.x
  41. Henstidge C.M., Balenga N.A.B., Ford L.A., Ross R.A., Waldhoer M., Irving A.J. // FASEB J. 2009. V. 23. P. 183–193. https://doi.org/10.1096/fj.08-108670
  42. Soderstrom K., Soliman E., Van Dross R. // Front. Pharmacol. 2017. V. 8. P. 720. https://doi.org/10.3389/fphar.2017.00720
  43. Sharir H., Abood M.E. // Pharmacol. Ther. 2010. V. 126. P. 301–313. https://doi.org/10.1016/j.pharmthera.2010.02.004
  44. Godlewski G., Offertáler L., Wagner J.A., Kunos G. // Prostaglandins Other Lipid Mediat. 2009. V. 89. P. 105–111. https://doi.org/10.1016/j.prostaglandins.2009.07.001
  45. Overton H.A., Babbs A.J., Doel S.M., Fyfe M.C.T., Gardner L.S., Griffin G., Jackson H.C., Procter M.J., Rasamison C.M., Tang-Christensen M., Widdowson P.S., Williams G.M., Reynet C. // Cell Metab. 2006. V. 3. P. 167–175. https://doi.org/10.1016/j.cmet.2006.02.004
  46. Zhao J., Zhao Y., Hu Y., Peng J. // Cell Mol. Biol. Lett. 2021. V. 26. P. 32. https://doi.org/10.1186/s11658-021-00264-x
  47. Hansen K.B., Rosenkilde M.M., Knop F.K., Wellner N., Diep T.A., Rehfeld J.F., Andersen U.B., Holst J.J., Hansen H.S. // J. Clin. Endocrinol. Metab. 2011. V. 96. P. E1409–E1417. https://doi.org/10.1210/jc.2011-0647
  48. Kogure R., Toyama K., Hiyamuta S., Kojima I., Takeda S. // Biochem. Biophys. Res. Commun. 2011. V. 416. P. 58–63. https://doi.org/10.1016/j.bbrc.2011.10.141
  49. Arifin S.A., Paternoster S., Carlessi R., Casari I., Ekberg J.H., Maffucci T., Newsholme P., Rosenkilde M.M., Falasca M. // Biochim. Biophys. Acta Mol. Cell Biol. Lipids. 2018. V. 1863. P. 1132–1141. https://doi.org/10.1016/j.bbalip.2018.06.007
  50. Zhu X., Huang W., Qi H. // GPR119 Agonists: A Novel Strategy for Type 2 Diabetes TreatmentInTech. 2013. https://doi.org/10.5772/48444
  51. Gantz I., Muraoka A., Yang Y.-K., Samuelson L.C., Zimmerman E.M., Cook H., Yamada T. // 3Genomics. 1997. V. 42. P. 462–466. https://doi.org/10.1006/geno.1997.4752
  52. Burstein S.H., McQuain C.A., Ross A.H., Salmonsen R.A., Zurier R.E. // J. Cell. Biochem. 2011. V. 112. P. 3227–3233. https://doi.org/10.1002/jcb.23245
  53. Kohno M., Hasegawa H., Inoue A., Muraoka M., Miyazaki T., Oka K., Yasukawa M. // Biochem. Biophys. Res. Commun. 2006. V. 347. P. 827–832. https://doi.org/10.1016/j.bbrc.2006.06.175
  54. Bradshaw H.B., Lee S.H., McHugh D. // Prostaglandins Other Lipid Mediat. 2009. V. 89. P. 131– 134. https://doi.org/10.1016/j.prostaglandins.2009.04.006
  55. MacIntyre J., Dong A., Straiker A., Zhu J., Howlett S.E., Bagher A., Denovan-Wright E., Yu D.-Y., Kelly M.E.M. // Eur. J. Pharmacol. 2014. V. 735. P. 105–114. https://doi.org/10.1016/j.ejphar.2014.03.055
  56. Morales P., Lago-Fernandez A., Hurst D.P., Sotudeh N., Brailoiu E., Reggio P.H., Abood M.E., Jagerovic N. // J. Med. Chem. 2020. V. 63. P. 14216– 14227. https://doi.org/10.1021/acs.jmedchem.0c00926
  57. Prömel S., Waller-Evans H., Dixon J., Zahn D., Colledge W.H., Doran J., Carlton M.B.L., Grosse J., Schöneberg T., Russ A.P., Langenhan T. // Dev. Dyn. 2012. V. 241. P. 1591–1602. https://doi.org/10.1002/dvdy.23841
  58. Lee J.-W., Huang B.X., Kwon H., Rashid M.A., Kharebava G., Desai A., Patnaik S., Marugan J., Kim H.-Y. // Nat. Commun. 2016. V. 7. P. 13123. https://doi.org/10.1038/ncomms13123
  59. Zhu X., Qian Y., Li X., Xu Z., Xia R., Wang N., Liang J., Yin H., Zhang A., Guo C., Wang G., He Y. // Nat. Commun. 2022. V. 13. P. 5513. https://doi.org/10.1038/s41467-022-33173-4
  60. Oh D.Y., Yoon J.M., Moon M.J., Hwang J.-I., Choe H., Lee J.Y., Kim J.I., Kim S., Rhim H., O’Dell D.K., Walker J.M., Na H.S., Lee M.G., Kwon H.B., Kim K., Seong J.Y. // J. Biol. Chem. 2008. V. 283. P. 21054–21064. https://doi.org/10.1074/jbc.m708908200
  61. Laun A.S., Shrader S.H., Brown K.J., Song Z.-H. // Acta Pharmacol. Sin. 2019. V. 40. P. 300–308. https://doi.org/10.1038/s41401-018-0031-9
  62. Uhlenbrock K., Gassenhuber H., Kostenis E. // Cell. Signal. 2002. V. 14. P. 941–953. https://doi.org/10.1016/s0898-6568(02)00041-4
  63. Thathiah A., Spittaels K., Hoffmann M., Staes M., Cohen A., Horré K., Vanbrabant M., Coun F., Baekelandt V., Delacourte A., Fischer D.F., Pollet D., De Strooper B., Merchiers P. // Science. 2009. V. 323. P. 946–951. https://doi.org/10.1126/science.1160649
  64. Isawi I.H., Morales P., Sotudeh N., Hurst D.P., Lynch D.L., Reggio P.H. // Molecules. 2020. V. 25. P. 725. https://doi.org/10.3390/molecules25030725
  65. Lin Z.-J., Lu X.-M., Zhu T.-J., Fang Y.-C., Gu Q.-Q., Zhu W. // Arch. Pharm. Res. 2008. V. 31. P. 1108– 1114. https://doi.org/10.1007/s12272-001-1276-4
  66. Allende G., Chávez-Reyes J., Guerrero-Alba R., Vázquez-León P., Marichal-Cancino B.A. // Front. Pharmacol. 2020. V. 11. P. 628. https://doi.org/10.3389/fphar.2020.00628
  67. Stančić A., Jandl K., Hasenöhrl C., Reichmann F., Marsche G., Schuligoi R., Heinemann A., Storr M., Schicho R. // Neurogastroenterol. Motil. 2015. V. 27. P. 1432–1445. https://doi.org/10.1111/nmo.12639
  68. Chiurchiù V., Lanuti M., De Bardi M., Battistini L., Maccarrone M. // Int. Immunol. 2015. V. 27. P. 153–160. https://doi.org/10.1093/intimm/dxu097
  69. Sharir H., Console-Bram L., Mundy C., Popoff S.N., Kapur A., Abood M.E. // J. Neuroimmune Pharmacol. 2012. V. 7. P. 856–865. https://doi.org/10.1007/s11481-012-9351-6
  70. Claff T., Ebenhoch R., Kley J.T., Magarkar A., Nar H., Weichert D. // Nat. Commun. 2025. V. 16. P. 1973. https://doi.org/10.1038/s41467-025-57204-y
  71. Oka S., Nakajima K., Yamashita A., Kishimoto S., Sugiura T. // Biochem. Biophys. Res. Commun. 2007. V. 362. P. 928–934. https://doi.org/10.1016/j.bbrc.2007.08.078
  72. Baker D., Pryce G., Davies W.L., Hiley C.R. // Trends Pharmacol. Sci. 2006. V. 27. P. 1–4. https://doi.org/10.1016/j.tips.2005.11.003
  73. Civelli O., Reinscheid R.K., Zhang Y., Wang Z., Fredriksson R., Schiöth H.B. // Annu. Rev. Pharmacol. Toxicol. 2013. V. 53. P. 127–146. https://doi.org/10.1146/annurev-pharmtox-010611-134548
  74. Petitet F., Donlan M., Michel A. // Chem. Biol. Drug Des. 2006. V. 67. P. 252–253. https://doi.org/10.1111/j.1747-0285.2006.00370.x
  75. Garland S.L. // SLAS Discov. 2013. V. 18. P. 947–966. https://doi.org/10.1177/1087057113498418
  76. Irving A., Abdulrazzaq G., Chan S.L.F., Penman J., Harvey J., Alexander S.P.H. // Adv. Pharmacol. 2017. V. 80. P. 223–247. https://doi.org/10.1016/bs.apha.2017.04.004
  77. Brown A.J. // Br. J. Pharmacol. 2007. V. 152. P. 567–575. https://doi.org/10.1038/sj.bjp.0707481
  78. Sharir H., Abood M.E. // Pharmacol. Ther. 2010. V. 126. P. 301–313. https://doi.org/10.1016/j.pharmthera.2010.02.004
  79. Sawzdargo M., Nguyen T., Lee D.K., Lynch K.R., Cheng R., Heng H.H.Q., George S.R., O’Dowd B.F. // Mol. Brain Res. 1999. V. 64. P. 193–198. https://doi.org/10.1016/s0169-328x(98)00277-0
  80. Waldeck-Weiermair M., Zoratti C., Osibow K., Balenga N., Goessnitzer E., Waldhoer M., Malli R., Graier W.F. // J. Cell Sci. 2008. V. 121. P. 1704–1717. https://doi.org/10.1242/jcs.020958
  81. Lauckner J.E., Jensen J.B., Chen H.-Y., Lu H.-C., Hille B., Mackie K. // Proc. Natl. Acad. Sci. USA. 2008. V. 105. P. 2699–2704. https://doi.org/10.1073/pnas.0711278105
  82. He Y., Shen H., Bi G.-H., Zhang H.-Y., Soler-Cedeño O., Alton H., Yang Y., Xi Z.-X. // Transl. Psychiatry. 2024. V. 14. P. 101. https://doi.org/10.1038/s41398-024-02820-3
  83. Staton P.C., Hatcher J.P., Walker D.J., Morrison A.D., Shapland E.M., Hughes J.P., Chong E., Mander P.K., Green P.J., Billinton A., Fulleylove M., Lancaster H.C., Smith J.C., Bailey L.T., Wise A., Brown A.J., Richardson J.C., Chessell I.P. // Pain. 2008. V. 139. P. 225–236. https://doi.org/10.1016/j.pain.2008.04.006
  84. Schuelert N., McDougall J.J. // Neurosci. Lett. 2011. V. 500. P. 72–76. https://doi.org/10.1016/j.neulet.2011.06.004
  85. Hu G., Ren G., Shi Y. // Oncogene. 2011. V. 30. P. 139–141. https://doi.org/10.1038/onc.2010.502
  86. Zhang X., Maor Y., Wang J., Kunos G., Groopman J. // Br. J. Pharmacol. 2010. V. 160. P. 1583–1594. https://doi.org/10.1111/j.1476-5381.2010.00841.x
  87. Ryberg E., Larsson N., Sjögren S., Hjorth S., Hermansson N., Leonova J., Elebring T., Nilsson K., Drmota T., Greasley P.J. // Br. J. Pharmacol. 2007. V. 152. P. 1092–1101. https://doi.org/10.1038/sj.bjp.0707460
  88. Sylantyev S., Jensen T.P., Ross R.A., Rusakov D.A. // Proc. Natl. Acad. Sci. USA. 2013. V. 110. P. 5193– 5198. https://doi.org/10.1073/pnas.1211204110
  89. Henstridge C.M., Balenga N.A.B., Ford L.A., Ross R.A., Waldhoer M., Irving A.J. // FASEB J. 2009. V. 23. P. 183–193. https://doi.org/10.1096/fj.08-108670
  90. Busse R., Edwards G., Félétou M., Fleming I., Vanhoutte P.M., Weston A.H. // Trends Pharmacol. Sci. 2002. V. 23. P. 374–380. https://doi.org/10.1016/s0165-6147(02)02050-3
  91. Abood M.E., Sorensen R.G., Stella N. (Eds.) // endo-CANNABINOIDS: Actions at Non-CB1/CB2 Cannabinoid Receptors. New York: Springer, V. 24. 2013. https://doi.org/10.1007/978-1-4614-4669-9
  92. Járai Z., Wagner J.A., Varga K., Lake K.D., Compton D.R., Martin B.R., Zimmer A.M., Bonner T.I., Buckley N.E., Mezey E., Razdan R.K., Zimmer A., Kunos G. // Proc. Natl. Acad. Sci. USA. 1999. V. 96. P. 14136–14141. https://doi.org/10.1073/pnas.96.24.14136
  93. White R., Hiley C.R. // Br. J. Pharmacol. 1997. V. 122. P. 1573–1584. https://doi.org/10.1038/sj.bjp.0701601
  94. Johns D.G., Behm D.J., Walker D.J., Ao Z., Shapland E.M., Daniels D.A., Riddick M., Dowell S., Staton P.C., Green P., Shabon U., Bao W., Aiyar N., Yue T., Brown A.J., Morrison A.D., Douglas S.A. // Br. J. Pharmacol. 2007. V. 152. P. 825–831. https://doi.org/10.1038/sj.bjp.0707462
  95. Oka S., Toshida T., Maruyama K., Nakajima K., Yamashita A., Sugiura T. // J. Biochem. 2009. V. 145. P. 13–20. https://doi.org/10.1093/jb/mvn136
  96. Kapur A., Zhao P., Sharir H., Bai Y., Caron M.G., Barak L.S., Abood M.E. // J. Biol. Chem. 2009. V. 284. P. 29817–29827. https://doi.org/10.1074/jbc.M109.027243
  97. Brenneman D.E., Petkanas D., Ippolito M., Ward S.J. // J. Mol. Neurosci. 2025. V. 75. P. 35. https://doi.org/10.1007/s12031-025-02326-7
  98. Bondarenko A., Waldeck-Weiermair M., Naghdi S., Poteser M., Malli R., Graier W.F. // Br. J. Pharmacol. 2010. V. 161. P. 308–320. https://doi.org/10.1111/j.1476-5381.2010.00744.x
  99. Akimov M.G., Gamisonia A.M., Dudina P.V., Gretskaya N.M., Gaydaryova A.A., Kuznetsov A.S., Zinchenko G.N., Bezuglov V.V. // Int. J. Mol. Sci. 2021. V. 22. P. 622. https://doi.org/10.3390/ijms22020622
  100. Ayakannu T., Taylor A.H., Konje J.C. // Histochem. Cell Biol. 2021. V. 156. P. 449–460. https://doi.org/10.1007/s00418-021-02018-4
  101. Ismail H.T.H., AbdelMageed M., Lindmark G., Hammarström M.-L., Hammarström S., Sitohy B. // Int. J. Mol. Sci. 2022. V. 23. P. 4556. https://doi.org/10.3390/ijms23094556
  102. Wang T., Xia K., Qiu T., Han S., Chen Z., Ma X., Zhang L., Zou J., Zhang Y., Yu B., Kong C., Guo J., Liu Y., Zhou J., Zheng S. // Aging (Albany NY). 2023. V. 15. P. 8930–8947. https://doi.org/10.18632/aging.204569
  103. Calvillo-Robledo A., Cervantes-Villagrana R.D., Morales P., Marichal-Cancino B.A. // Life Sci. 2022. V. 301. P. 120596. https://doi.org/10.1016/j.lfs.2022.120596
  104. Nakajima K., Oka S., Tanikawa T., Nemoto-Sasaki Y., Matsumoto N., Ishiguro H., Arata Y., Sugiura T., Yamashita A. // Int. J. Mol. Sci. 2022. V. 23. P. 10932. https://doi.org/10.3390/ijms231810932
  105. Kolbe M.R., Hohmann T., Hohmann U., Maronde E., Golbik R., Prell J., Illert J., Strauss C., Dehghani F. // Cells. 2023. V. 12. P. 2646. https://doi.org/10.3390/cells12222646
  106. Martínez-Pinilla E., Reyes-Resina I., Oñatibia-Astibia A., Zamarbide M., Ricobaraza A., Navarro G., Moreno E., Dopeso-Reyes I.G., Sierra S., Rico A.J., Roda E., Lanciego J.L., Franco R. // Exp. Neurol. 2014. V. 261. P. 44–52. https://doi.org/10.1016/j.expneurol.2014.05.008
  107. Moreno E., Andradas C., Medrano M., Caffarel M.M., Pérez-Gómez E., Blasco-Benito S., Gómez-Cañas M., Pazos M.R., Irving A.J., Lluís C., Canela E.I., Fernández-Ruiz J., Guzmán M., McCormick P.J., Sánchez C. // J. Biol. Chem. 2014. V. 289. P. 21960– 21972. https://doi.org/10.1074/jbc.M114.571747
  108. Norregaard K., Benned-Jensen T., Marie Rosenkilde M. // 6CTMC. 2011. V. 11. P. 618–628. https://doi.org/10.2174/1874467210902020140
  109. Gantz I., Muraoka A., Yang Y.-K., Samuelson L.C., Zimmerman E.M., Cook H., Yamada T. // 3Genomics. 1997. V. 42. P. 462–466. https://doi.org/10.1006/geno.1997.4752
  110. Huang S.M., Bisogno T., Petros T.J., Chang S.Y., Zavitsanos P.A., Zipkin R.E., Sivakumar R., Coop A., Maeda D.Y., De Petrocellis L., Burstein S., Di Marzo V., Walker J.M. // J. Biol. Chem. 2001. V. 276. P. 42639–42644. https://doi.org/10.1074/jbc.m107351200
  111. Burstein S.H., McQuain C.A., Ross A.H., Salmonsen R.A., Zurier R.E. // J. Cell. Biochem. 2011. V. 112. P. 3227–3233. https://doi.org/10.1002/jcb.23245
  112. Rimmerman N., Bradshaw H.B., Hughes H.V., Chen J.S.-C., Hu S.S.-J., McHugh D., Vefring E., Jahnsen J.A., Thompson E.L., Masuda K., Cravatt B.F., Burstein S., Vasko M.R., Prieto A.L., O’Dell D.K., Walker J.M. // Mol. Pharmacol. 2008. V. 74. P. 213–224. https://doi.org/10.1124/mol.108.045997
  113. Wiles A.L., Pearlman R., Rosvall M., Aubrey K.R., Vandenberg R.J. // J. Neurochem. 2006. V. 99. P. 781–786. https://doi.org/10.1111/j.1471-4159.2006.04107.x
  114. Jeong H., Vandenberg R.J., Vaughan C.W. // Br. J. Pharmacol. 2010. V. 161. P. 925–935. https://doi.org/10.1111/j.1476-5381.2010.00935.x
  115. Yang Z., Aubrey K.R., Alroy I., Harvey R.J., Vandenberg R.J., Lynch J.W. // Biochem. Pharmacol. 2008. V. 76. P. 1014–1023. https://doi.org/10.1016/j.bcp.2008.07.037
  116. Parmar N., Ho W.V. // Br. J. Pharmacol. 2010. V. 160. P. 594–603. https://doi.org/10.1111/j.1476-5381.2009.00622.x
  117. Bondarenko A.I., Panasiuk O., Drachuk K., Montecucco F., Brandt K.J., Mach F. // Vasc. Pharmacol. 2018. V. 102. P. 44–55. https://doi.org/10.1016/j.vph.2018.01.004
  118. Ikeda Y., Iguchi H., Nakata M., Ioka R.X., Tanaka T., Iwasaki S., Magoori K., Takayasu S., Yamamoto T.T., Kodama T., Yada T., Sakurai T., Yanagisawa M., Sakai J. // Biochem. Biophys. Res. Commun. 2005. V. 333. P. 778–786. https://doi.org/10.1016/j.bbrc.2005.06.005
  119. Kohno M., Hasegawa H., Inoue A., Muraoka M., Miyazaki T., Oka K., Yasukawa M. // Biochem. Biophys. Res. Commun. 2006. V. 347. P. 827–832. https://doi.org/10.1016/j.bbrc.2006.06.175
  120. McHugh D., Hu S.S., Rimmerman N., Juknat A., Vogel Z., Walker J.M., Bradshaw H.B. // BMC Neurosci. 2010. V. 11. P. 44. https://doi.org/10.1186/1471-2202-11-44
  121. McHugh D., Roskowski D., Xie S., Bradshaw H.B. // Front. Pharmacol. 2014. V. 4. P. 1–8. https://doi.org/ 10.3389/fphar.2013.00162
  122. McHugh D., Page J., Dunn E., Bradshaw H.B. // Br. J. Pharmacol. 2012. V. 165. P. 2414–2424. https://doi.org/10.1111/j.1476-5381.2011.01497.x
  123. McHugh D., Wager-Miller J., Page J., Bradshaw H.B. // J. Mol. Signal. 2012. V. 7. P. 10. https://doi.org/10.1186/1750-2187-7-10
  124. Flegel C., Vogel F., Hofreuter A., Wojcik S., Schoeder C., Kieć-Kononowicz K., Brockmeyer N.H., Müller C.E., Becker C., Altmüller J., Hatt H., Gisselmann G. // Sci. Rep. 2016. V. 6. P. 32255. https://doi.org/10.1038/srep32255
  125. Morales P., Lago-Fernandez A., Hurst D.P., Sotudeh N., Brailoiu E., Reggio P.H., Abood M.E., Jagerovic N. // J. Med. Chem. 2020. V. 63. P. 14216– 14227. https://doi.org/10.1021/acs.jmedchem.0c00926
  126. Lu V.B., Puhl H.L., Ikeda S.R. // Mol. Pharmacol. 2013. V. 83. P. 267–282. https://doi.org/10.1124/mol.112.081182
  127. Console-Bram L., Brailoiu E., Brailoiu G.C., Sharir H., Abood M.E. // Br. J. Pharmacol. 2014. V. 171. P. 3908–3917. https://doi.org/10.1111/bph.12746
  128. Abdulrazzaq G., Chan N., Alexander S. // 2015. Nova Scotia-Canada. the 25th Anneversaray of the International Cannabinoid Research Society 2015. Conference poster .
  129. MacIntyre J., Dong A., Straiker A., Zhu J., Howlett S.E., Bagher A., Denovan-Wright E., Yu D.-Y., Kelly M.E.M. // Eur. J. Pharmacol. 2014. V. 735. P. 105–114. https://doi.org/10.1016/j.ejphar.2014.03.055
  130. Penumarti A., Abdel-Rahman A.A. // J. Pharmacol. Exp. Ther. 2014. V. 349. P. 29–38. https://doi.org/10.1124/jpet.113.209213
  131. Qin Y., Verdegaal E.M.E., Siderius M., Bebelman J.P., Smit M.J., Leurs R., Willemze R., Tensen C.P., Osanto S. // Pigment Cell Melanoma Res. 2011. V. 24. P. 207–218. https://doi.org/10.1111/j.1755-148X.2010.00781.x
  132. Chiang N., Dalli J., Colas R.A., Serhan C.N. // J. Exp. Med. 2015. V. 212. P. 1203–1217. https://doi.org/10.1084/jem.20150225
  133. Honkisz-Orzechowska E., Łażewska D., Baran G., Kieć-Kononowicz K. // Molecules. 2024. V. 29. P. 1258. https://doi.org/10.3390/molecules29061258
  134. Davenport A.P., Alexander S.P.H., Sharman J.L., Pawson A.J., Benson H.E., Monaghan A.E., Liew W.C., Mpamhanga C.P., Bonner T.I., Neubig R.R., Pin J.P., Spedding M., Harmar A.J. // Pharmacol. Rev. 2013. V. 65. P. 967–986. https://doi.org/10.1124/pr.112.007179
  135. Finlay D.B., Joseph W.R., Grimsey N.L., Glass M. // PeerJ. 2016. V. 4. P. e1835. https://doi.org/10.7717/peerj.1835
  136. Takenouchi R., Inoue K., Kambe Y., Miyata A. // Biochem. Biophys. Res. Commun. 2012. V. 418. P. 366–371. https://doi.org/10.1016/j.bbrc.2012.01.027
  137. Chiang N., De La Rosa X., Libreros S., Serhan C.N. // J. Immunol. 2017. V. 198. P. 842–851. https://doi.org/10.4049/jimmunol.1601650
  138. Reyes-Resina I., Navarro G., Aguinaga D., Canela E.I., Schoeder C.T., Załuski M., Kieć-Kononowicz K., Saura C.A., Müller C.E., Franco R. // Biochem. Pharmacol. 2018. V. 157. P. 169–179. https://doi.org/10.1016/j.bcp.2018.06.001
  139. Amisten S., Braun O.Ö., Bengtsson A., Erlinge D. // Thromb. Res. 2008. V. 122. P. 47–57. https://doi.org/10.1016/j.thromres.2007.08.014
  140. Kotarsky K., Boketoft A., Bristulf J., Nilsson N.E., Norberg A., Hansson S., Owman C., Sillard R., Leeb- Lundberg L.M.F., Olde B. // J. Pharmacol. Exp. Ther. 2006. V. 318. P. 619–628. https://doi.org/10.1124/jpet.105.098848
  141. Williams J.R., Khandoga A.L., Goyal P., Fells J.I., Perygin D.H., Siess W., Parrill A.L., Tigyi G., Fujiwara Y. // J. Biol. Chem. 2009. V. 284. P. 17304– 17319. https://doi.org/10.1074/jbc.M109.003194
  142. Lee C.-W., Rivera R., Dubin A.E., Chun J. // J. Biol. Chem. 2007. V. 282. P. 4310–4317. https://doi.org/10.1074/jbc.M610826200
  143. Khandoga A.L., Pandey D., Welsch U., Brandl R., Siess W. // Cardiovasc. Res. 2011. V. 90. P. 157– 164. https://doi.org/10.1093/cvr/cvq369
  144. Wellendorph P., Johansen L.D., Bräuner-Osborne H. // Vitam. Horm. 2010. V. 84. P. 151–184. https://doi.org/10.1124/mol.109.055244
  145. De Souza C.O., Paschoal V.A., Sun X., Vishvanath L., Zhang Q., Shao M., Onodera T., Chen S., Joffin N., Bueno L.M.A., Gupta R.K., Oh D.Y. // J. Clin. Invest. 2022. V. 132. P. e160097. https://doi.org/10.1172/JCI160097
  146. Oh D.Y., Yoon J.M., Moon M.J., Hwang J.-I., Choe H., Lee J.Y., Kim J.I., Kim S., Rhim H., O’Dell D.K., Walker J.M., Na H.S., Lee M.G., Kwon H.B., Kim K., Seong J.Y. // J. Biol. Chem. 2008. V. 283. P. 21054– 21064. https://doi.org/10.1074/jbc.M708908200
  147. Hu J., Oda S.K., Shotts K., Donovan E.E., Strauch P., Pujanauski L.M., Victorino F., Al-Shami A., Fujiwara Y., Tigyi G., Oravecz T., Pelanda R., Torres R.M. // J. Immunol. 2014. V. 193. P. 85–95. https://doi.org/10.4049/jimmunol.1300429
  148. Paugh S.W., Cassidy M.P., He H., Milstien S., Sim-Selley L.J., Spiegel S., Selley D.E. // Mol. Pharmacol. 2006. V. 70. P. 41–50. https://doi.org/10.1124/mol.105.020552
  149. Dacheux M.A., Norman D.D., Tigyi G.J., Lee S.C. // Pharmacol. Ther. 2023. V. 245. P. 108414. https://doi.org/10.1016/j.pharmthera.2023.108414
  150. Lee J.-W., Huang B.X., Kwon H., Rashid M.A., Kharebava G., Desai A., Patnaik S., Marugan J., Kim H.-Y. // Nat. Commun. 2016. V. 7. P. 13123. https://doi.org/10.1038/ncomms13123
  151. Huang B.X., Hu X., Kwon H.-S., Fu C., Lee J.-W., Southall N., Marugan J., Kim H.-Y. // Commun. Biol. 2020. V. 3. P. 109. https://doi.org/10.1038/s42003-020-0831-6
  152. Kim H.-Y., Spector A.A. // Mol. Asp. Med. 2018. V. 64. P. 34–44. https://doi.org/org/10.1016/j.mam.2018.03.004
  153. Kwon H.-S., Kevala K., Qian H., Abu-Asab M., Patnaik S., Marugan J., Kim H.-Y. // Int. J. Mol. Sci. 2023. V. 24. P. 5340. https://doi.org/10.3390/ijms24065340
  154. Huang B.X., Chen H., Joo Y., Kwon H.-S., Fu C., Spector A.A., Kim H.-Y. // iScience. 2023. V. 26. P. 106550. https://doi.org/10.1016/j.isci.2023.106550
  155. Bhat R.R., Yadav P., Sahay D., Bhargava D.K., Creighton C.J., Yazdanfard S., Alrawi A., Yadav V., Qin L., Nanda S., Sethunath V., Fu X., De Angelis C., Narkar V.A., Osborne C.K., Schiff R., Trivedi M.V. // Breast Cancer Res. Treat. 2018. V. 170. P. 279–292. https://doi.org/10.1007/s10549-018-4751-9
  156. Abdulkareem N.M., Bhat R., Qin L., Vasaikar S., Gopinathan A., Mitchell T., Shea M.J., Nanda S., Thangavel H., Zhang B., De Angelis C., Schiff R., Trivedi M.V. // FASEB J. 2021. V. 35. P. e21719. https://doi.org//10.1096/fj.202100070R
  157. Jones D.T.D., Dates A.N., Rawson S.D., Burruss M.M., Lipper C.H., Blacklow S.C. // Nat. Commun. 2023. V. 14. P. 2490. https://doi.org/10.1038/s41467-023-38083-7
  158. Nam H.-J., Kim Y.-J., Kang J.-H., Lee S.-J. // Cell Death Discov. 2022. V. 8. P. 271. https://doi.org/10.1038/s41420-022-01053-x
  159. Ma B., Zhu J., Tan J., Mao Y., Tang L., Shen C., Zhang H., Kuang Y., Fei J., Yang X., Wang Z. // Am. J. Cancer Res. 2017. V. 7. P. 433–447. https://doi.org/10.7150/ajcr.17463
  160. Kim H.-Y., Huang B.X., Spector A.A. // Int. J. Mol. Sci. 2022. V. 23. P. 4635. https://doi.org/10.3390/ijms23094635
  161. Kwon H.-S., Kevala K., Qian H., Abu-Asab M., Patnaik S., Marugan J., Kim H.-Y. // Int. J. Mol. Sci. 2023. V. 24. P. 5340. https://doi.org/10.3390/ijms24065340
  162. Park T., Chen H., Kim H.-Y. // J. Neuroinflammation. 2019. V. 16. P. 225. https://doi.org/10.1186/s12974-019-1621-2
  163. Soga T., Ohishi T., Matsui T., Saito T., Matsumoto M., Takasaki J., Matsumoto S., Kamohara M., Hiyama H., Yoshida S., Momose K., Ueda Y., Matsushime H., Kobori M., Furuichi K. // Biochem. Biophys. Res. Commun. 2005. V. 326. P. 744–751. https://doi.org/10.1016/j.bbrc.2004.11.120
  164. Chu Z.-L., Carroll C., Alfonso J., Gutierrez V., He H., Lucman A., Pedraza M., Mondala H., Gao H., Bagnol D., Chen R., Jones R.M., Behan D.P., Leonard J. // Endocrinology. 2008. V. 149. P. 2038–2047. https://doi.org/10.1210/en.2007-0966
  165. Lauffer L.M., Iakoubov R., Brubaker P.L. // Diabetes. 2009. V. 58. P. 1058–1066. https://doi.org/10.2337/db08-1237
  166. Cornall L.M., Mathai M.L., Hryciw D.H., McAinch A.J. // Drug Discov. Today. 2014. V. 19. P. 670– 679. https://doi.org/10.1016/j.drudis.2013.11.021
  167. Yang J.W., Kim H.S., Im J.H., Kim J.W., Jun D.W., Lim S.C., Lee K., Choi J.M., Kim S.K., Kang K.W. // FASEB J. 2016. V. 30. P. 324–335. https://doi.org/10.1096/fj.15-273771
  168. Gerlach L., Beyer A.-S.L., Kaemmerer D., Sänger J., Evert K., Schulz S., Lupp A. // Sci. Rep. 2023. V. 13. P. 18993. https://doi.org/10.1038/s41598-023-46395-3
  169. Yamaguchi Y., Murai I., Goto K., Doi S., Zhou H., Setsu G., Shimatani H., Okamura H., Miyake T., Doi M. // Sci. Rep. 2021. V. 11. P. 22406. https://doi.org/10.1038/s41598-021-01764-8
  170. Zhu X., Huang W., Qi H. // In: Oguntibeju O. (Ed.) Diabetes Mellitus - Insights and Perspectives. InTech, 2013. https://doi.org/10.5772/48444
  171. Chu Z.-L., Jones R.M., He H., Carroll C., Gutierrez V., Lucman A., Moloney M., Gao H., Mondala H., Bagnol D., Unett D., Liang Y., Demarest K., Semple G., Behan D.P., Leonard J. // Endocrinology. 2007. V. 148. P. 2601–2609. https://doi.org/10.1210/en.2007-0966
  172. Lan H., Vassileva G., Corona A., Liu L., Baker H., Golovko A., Abbondanzo S.J., Hu W., Yang S., Ning Y., Del Vecchio R.A., Poulet F., Laverty M., Gustafson E.L., Hedrick J.A., Kowalski T.J. // J. Endocrinol. 2009. V. 201. P. 219–230. https://doi.org/10.1677/JOE-08-0453
  173. Semple G., Fioravanti B., Pereira G., Calderon I., Uy J., Choi K., Xiong Y., Ren A., Morgan M., Dave V., Thomsen W., Unett D.J., Xing C., Bossie S., Carroll C., Chu Z.-L., Grottick A.J., Hauser E.K., Leonard J., Jones R.M. // J. Med. Chem. 2008. V. 51. P. 5172– 5175. https://doi.org/10.1021/jm8006867
  174. Flock G., Holland D., Seino Y., Drucker D.J. // Endocrinology. 2011. V. 152. P. 374–383. https://doi.org/10.1210/en.2010-1047
  175. Overton H.A., Babbs A.J., Doel S.M., Fyfe M.C.T., Gardner L.S., Griffin G., Jackson H.C., Procter M.J., Rasamison C.M., Tang-Christensen M., Widdowson P.S., Williams G.M., Reynet C. // Cell Metab. 2006. V. 3. P. 167–175. https://doi.org/10.1016/j.cmet.2006.02.004
  176. Chu Z.-L., Carroll C., Chen R., Alfonso J., Gutierrez V., He H., Lucman A., Xing C., Sebring K., Zhou J., Wagner B., Unett D., Jones R.M., Behan D.P., Leonard J. // Mol. Endocrinol. 2010. V. 24. P. 161–170. https://doi.org/10.1210/me.2009-0239
  177. Syed S.K., Bui H.H., Beavers L.S., Farb T.B., Ficorilli J., Chesterfield A.K., Kuo M.-S., Bokvist K., Barrett D.G., Efanov A.M. // Am. J. Physiol. Endocrinol. Metab. 2012. V. 303. P. https://doi.org/10.3390/ijms22031034E1469–E1478
  178. Im D.-S. // Int. J. Mol. Sci. 2021. V. 22. P. 1034. https://doi.org/10.1152/ajpendo.00269.2012
  179. Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodríguez De Fonseca F., Rosengarth A., Luecke H., Di Giacomo B., Tarzia G., Piomelli D. // Nature. 2003. V. 425. P. 90–93. https://doi.org/10.1038/nature01921
  180. Gaetani S., Fu J., Cassano T., Dipasquale P., Romano A., Righetti L., Cianci S., Laconca L., Giannini E., Scaccianoce S., Mairesse J., Cuomo V., Piomelli D. // J. Neurosci. 2010. V. 30. P. 8096–8101. https://doi.org/10.1523/JNEUROSCI.0036-10.2010
  181. Sun Y., Alexander S.P.H., Garle M.J., Gibson C.L., Hewitt K., Murphy S.P., Kendall D.A., Bennett A.J. // Br. J. Pharmacol. 2007. V. 152. P. 734–743. https://doi.org/10.1038/sj.bjp.0707478
  182. Bilbao A., Blanco E., Luque-Rojas M.J., Suárez J., Palomino A., Vida M., Araos P., Bermúdez-Silva F.J., Fernández-Espejo E., Spanagel R., Rodríguez De Fonseca F. // Addiction Biol. 2013. V. 18. P. 78–87. https://doi.org/10.1111/adb.12006
  183. Bilbao A., Serrano A., Cippitelli A., Pavón F.J., Giuffrida A., Suárez J., García-Marchena N., Baixeras E., Gómez De Heras R., Orio L., Alén F., Ciccocioppo R., Cravatt B.F., Parsons L.H., Piomelli D., Rodríguez De Fonseca F. // Addiction Biol. 2016. V. 21. P. 859–872. https://doi.org/10.1111/adb.12276
  184. Fan A., Wu X., Wu H., Li L., Huang R., Zhu Y., Qiu Y., Fu J., Ren J., Zhu C. // PLoS ONE. 2014. V. 9. P. e85337. https://doi.org//10.1371/journal.pone.0085337
  185. Ahern G.P. // J. Biol. Chem. 2003. V. 278. P. 30429– 30434. https://doi.org/10.1074/jbc.M305051200
  186. Rahnasto-Rilla M., Kokkola T., Jarho E., Lahtela- Kakkonen M., Moaddel R. // ChemBioChem. 2016. V. 17. P. 77–81. https://doi.org/10.1002/cbic.201500482
  187. Hansen K.B., Rosenkilde M.M., Knop F.K., Wellner N., Diep T.A., Rehfeld J.F., Andersen U.B., Holst J.J., Hansen H.S. // J. Clin. Endocrinol. Metab. 2011. V. 96. P. E1409–E1417. https://doi.org/10.1210/jc.2011-0647
  188. Ning Y., O’Neill K., Lan H., Pang L., Shan L.X., Hawes B.E., Hedrick J.A. // Br. J. Pharmacol. 2008. V. 155. P. 1056–1065. https://doi.org/10.1038/bjp.2008.337
  189. Engelstoft M.S., Norn C., Hauge M., Holliday N.D., Elster L., Lehmann J., Jones R.M., Frimurer T.M., Schwartz T.W. // Br. J. Pharmacol. 2014. V. 171. P. 5774–5789. https://doi.org/10.1111/bph.12877
  190. Cox H.M., Tough I.R., Woolston A.-M., Zhang L., Nguyen A.D., Sainsbury A., Herzog H. // Cell Metab. 2010. V. 11. P. 532–542. https://doi.org/10.1016/j.cmet.2010.04.014
  191. Kogure R., Toyama K., Hiyamuta S., Kojima I., Takeda S. // Biochem. Biophys. Res. Commun. 2011. V. 416. P. 58–63. https://doi.org/10.1016/j.bbrc.2011.10.141
  192. Hansen H.S., Rosenkilde M.M., Holst J.J., Schwartz T.W. // Trends Pharmacol. Sci. 2012. V. 33. P. 374–381. https://doi.org/10.1016/j.tips.2012.03.014
  193. Cvijanovic N., Isaacs N.J., Rayner C.K., Feinle-Bisset C., Young R.L., Little T.J. // Int. J. Obes. 2017. V. 41. P. 233–239. https://doi.org/10.1038/ijo.2016.199
  194. Hassing H.A., Fares S., Larsen O., Pad H., Hauge M., Jones R.M., Schwartz T.W., Hansen H.S., Rosenkilde M.M. // Biochem. Pharmacol. 2016. V. 119. P. 66–75. https://doi.org/10.1038/ijo.2016.199
  195. Lu Y., Hatzipantelis C.J., Langmead C.J., Stewart G.D. // Br. J. Pharmacol. 2024. V. 181. P. 2095–2113. https://doi.org/10.1111/bph.16221
  196. Bjursell M., Gerdin A.-K., Jönsson M., Surve V.V., Svensson L., Huang X.-F., Törnell J., Bohlooly-Y M. // Biochem. Biophys. Res. Commun. 2006. V. 348. P. 359–366. https://doi.org/10.1016/j.bbrc.2006.07.090
  197. Godlewski G., Jourdan T., Szanda G., Tam J., Resat Cinar, Harvey-White J., Liu J., Mukhopadhyay B., Pacher P., Ming Mo F., Osei-Hyiaman D., George Kunos M. // Sci. Rep. 2015. V. 5. P. 14953. https://doi.org/10.1038/srep14953
  198. Laun A.S., Shrader S.H., Brown K.J., Song Z.-H. // Acta Pharmacol. Sin. 2019. V. 40. P. 300–308. https://doi.org/10.1038/s41401-018-0031-9
  199. Hinckley M., Vaccari S., Horner K., Chen R., Conti M. // Dev. Biol. 2005. V. 287. P. 249–261. https://doi.org/10.1016/j.ydbio.2005.08.019
  200. Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y. // J. Biol. Chem. 2007. V. 282. P. 10506–10515. https://doi.org/10.1074/jbc.M700911200
  201. Uhlenbrock K., Gassenhuber H., Kostenis E. // Cell Signal. 2002. V. 14. P. 941–953. https://doi.org/10.1016/s0898-6568(02)00041-4
  202. Thathiah A., Spittaels K., Hoffmann M., Staes M., Cohen A., Horré K., Vanbrabant M., Coun F., Baekelandt V., Delacourte A., Fischer D.F., Pollet D., De Strooper B., Merchiers P. // Science. 2009. V. 323. P. 946– 951. https://doi.org/10.1016/s0898-6568(02)00041-4
  203. Huang Y., Skwarek-Maruszewska A., Horré K., Vandewyer E., Wolfs L., Snellinx A., Saito T., Radaelli E., Corthout N., Colombelli J., Lo A.C., Van Aerschot L., Callaerts-Vegh Z., Trabzuni D., Bossers K., Verhaagen J., Ryten M., Munck S., D’Hooge R., Swaab D.F., Hardy J., Saido T.C., De Strooper B., Thathiah A. // Sci. Transl. Med. 2015. V. 7. P. 309. https://doi.org/10.1126/scitranslmed.aab3492
  204. Ye C., Zhang Z., Wang Z., Hua Q., Zhang R., Xie X. // J. Pharmacol. Exp. Ther. 2014. V. 349. P. 437–443. https://doi.org/10.1124/jpet.114.213082
  205. Chang H., Li X., Tu H., Wu L., Yu Y., Liu J., Chen N., Shen W.L., Hua T. // Cell Rep. 2025. V. 44. P. 115478. https://doi.org/10.1016/j.celrep.2025.115478
  206. Eggerickx D., Denef J.F., Labbe O., Hayashi Y., Refetoff S., Vassart G., Parmentier M., Libert F. // Biochem. J. 1995. V. 309. P. 837–843. https://doi.org/10.1042/bj3090837
  207. Sveidahl Johansen O., Ma T., Hansen J.B., Markussen L.K., Schreiber R., Reverte-Salisa L., Dong H., Christensen D.P., Sun W., Gnad T., Karavaeva I., Nielsen T.S., Kooijman S., Cero C., Dmytriyeva O., Shen Y., Razzoli M., O’Brien S.L., Kuipers E.N., Nielsen C.H., Orchard W., Willemsen N., Jespersen N.Z., Lundh M., Sustarsic E.G., Hallgren C.M., Frost M., McGonigle S., Isidor M.S., Broholm C., Pedersen O., Hansen J.B., Grarup N., Hansen T., Kjær A., Granneman J.G., Babu M.M., Calebiro D., Nielsen S., Rydén M., Soccio R., Rensen P.C.N., Treebak J.T., Schwartz T.W., Emanuelli B., Bartolomucci A., Pfeifer A., Zechner R., Scheele C., Mandrup S., Gerhart-Hines Z. // Cell. 2021. V. 184. P. 3502–3518.e33. https://doi.org/10.1016/j.cell.2021.04.037
  208. Zhang B., Li Y., Ding J., Dong F., Hou Y., Jiang B., Shi F., Xu Y. // J. Zhejiang Univ. Sci. B. 2012. V. 13. P. 555–566. https://doi.org/10.1631/jzus.B1100353
  209. Tanaka S., Miyagi T., Dohi E., Seki T., Hide I., Sotomaru Y., Saeki Y., Antonio Chiocca E., Matsumoto M., Sakai N. // Neurobiol. Dis. 2014. V. 68. P. 215–227. https://doi.org/10.1016/j.nbd.2014.04.007
  210. Tanaka S., Shimada N., Shiraki H., Miyagi T., Harada K., Hide I., Sakai N. // Mol. Cell. Neurosci. 2022. V. 118. P. 103691. https://doi.org//10.1016/j.mcn.2021.103691
  211. Miyagi T., Tanaka S., Hide I., Shirafuji T., Sakai N. // PLoS One. 2016. V. 11. P. e0147466. https://doi.org/org/10.1371/journal.pone.0147466
  212. Huang Y., Rafael Guimarães T., Todd N., Ferguson C., Weiss K.M., Stauffer F.R., McDermott B., Hurtle B.T., Saito T., Saido T.C., MacDonald M.L., Homanics G.E., Thathiah A. // Proc. Natl. Acad. Sci. USA. 2022. V. 119. P. e2204828119. https://doi.org/10.1073/pnas.2204828119
  213. Benoit M.E., Hernandez M.X., Dinh M.L., Benavente F., Vasquez O., Tenner A.J. // J. Biol. Chem. 2013. V. 288. P. 654–665. https://doi.org/10.1074/jbc.M112.400168
  214. Oeckl P., Hengerer B., Ferger B. // Exp. Neurol. 2014. V. 257. P. 1–9. https://doi.org/10.1016/j.expneurol.2014.04.010
  215. Ruiz-Medina J., Ledent C., Valverde O. // Neuro-pharmacology. 2011. V. 61. P. 43–50. https://doi.org/10.1016/j.neuropharm.2011.02.014
  216. Tourino C., Valjent E., Ruiz-Medina J., Herve D., Ledent C., Valverde O. // Br. J. Pharmacol. 2012. V. 167. P. 892–904. https://doi.org/10.1111/j.1476-5381.2012.02043.x
  217. Isawi I.H., Morales P., Sotudeh N., Hurst D.P., Lynch D.L., Reggio P.H. // Molecules. 2020. V. 25. P. 725. https://doi.org/10.3390/molecules25030725
  218. Ignatov A., Lintzel J., Kreienkamp H.-J., Chica Schaller H. // Biochem. Biophys. Res. Commun. 2003. V. 311. P. 329–336. https://doi.org/ 10.1016/j.bbrc.2003.10.006
  219. Morales P., Isawi I., Reggio P.H. // Drug Metab. Rev. 2018. V. 50. P. 74–93. https://doi.org/10.1080/03602532.2018.1428616
  220. Lu X., Zhang N., Meng B., Dong S., Hu Y. // Mol. Cell Biochem. 2012. V. 366. P. 101–110. https://doi.org/10.1007/s11010-012-1287-x
  221. Lin Z.-J., Lu X.-M., Zhu T.-J., Fang Y.-C., Gu Q.-Q., Zhu W. // Arch. Pharm. Res. 2008. V. 31. P. 1108–1114. https://doi.org/10.1007/s12272-001-1276-4
  222. Zhang M., Yang X., Chen S., Jia W., Ma X., Wang J., Qian Y., Lei D., Liu H., Pan X. // Thorac. Cancer. 2021. V. 12. P. 1525–1535. https://doi.org/10.1111/1759-7714.13933
  223. Ignatov A., Lintzel J., Hermans-Borgmeyer I., Kreienkamp H.-J., Joost P., Thomsen S., Methner A., Schaller H.C. // J. Neurosci. 2003. V. 23. P. 907–914. https://doi.org/10.1523/JNEUROSCI.23-03-00907.2003
  224. Meyer Zu Heringdorf D., Lass H., Kuchar I., Lipinski M., Alemany R., Rümenapp U., Jakobs K.H. // Eur. J. Pharmacol. 2001. V. 414. P. 145–154. https://doi.org/10.1016/s0014-2999(01)00789-0
  225. Wang L., Yang D., Zhang Y., Jiao Y. // Front. Oncol. 2022. V. 12. P. 932689. https://doi.org/10.3389/fonc.2022.932689
  226. Lu X., Zhang N., Dong S., Hu Y. // Brain Res. Bull. 2012. V. 87. P. 30–36. https://doi.org/10.1016/j.brainresbull.2011.09.020
  227. Lu X., Zhang N., Meng B., Dong S., Hu Y. // Mol. Cell Biochem. 2012. V. 366. P. 101–110. https://doi.org/10.1007/s11010-012-1287-x
  228. Brown K.J., Laun A.S., Song Z.-H. // Biochem. Biophys. Res. Commun. 2017. V. 493. P. 451–454. https://doi.org/10.1016/j.bbrc.2017.09.001
  229. Ali S., Wang P., Murphy R.E., Allen J.A., Zhou J. // Drug Discov. Today. 2024. V. 29. P. 103922. https://doi.org/org/10.1016/j.drudis.2024.103922
  230. Stott L.A., Brighton C.A., Brown J., Mould R., Bennett K.A., Newman R., Currinn H., Autore F., Higueruelo A.P., Tehan B.G., MacSweeney C., O’Brien M.A., Watson S.P. // Heliyon. 2021. V. 7. P. e07201. https://doi.org/10.1016/j.heliyon.2021.e07201

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2025 Russian Academy of Sciences