Effect of Low Molecular Weight Nerve Growth Factor Mimetic GK-2 on Cognitive Function and Synaptic Transmission in Hippocampal Slices

A. A. Volkova; Волкова А. А.; P. Yu. Povarnina; Поварнина П. Ю.; P. D. Rogozin; Рогозин П. Д.; R. V. Kondratenko; Кондратенко Р. В.; I. N. Sharonova; Шаронова И. Н.; A. A. Kamensky; Каменский А. А.; V. G. Skrebitsky; Скребицкий В. Г.

doi:10.31857/S1027813323020188

Effect of Low Molecular Weight Nerve Growth Factor Mimetic GK-2 on Cognitive Function and Synaptic Transmission in Hippocampal Slices

作者: Volkova A.A.¹^,2, Povarnina P.Y.¹, Rogozin P.D.³, Kondratenko R.V.³, Sharonova I.N.³, Kamensky A.A.², Skrebitsky V.G.³
隶属关系:
1. Research Zakusov Institute of Pharmacology
2. Lomonosov Moscow State University, Faculty of Biology
3. Research Center of Neurology
期: 卷 40, 编号 2 (2023)
页面: 166-171
栏目: Experimental Articles
URL: https://transsyst.ru/1027-8133/article/view/653947
DOI: https://doi.org/10.31857/S1027813323020188
EDN: https://elibrary.ru/UDDMTT
ID: 653947

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详细

Nerve growth factor (NGF) contributes to the proliferation, differentiation and maintenance of the viability and functioning of peripheral and central neurons. At the Research Zakusov Institute of Pharmacology a dimeric dipeptide mimetic of the NGF loop 4 bis(monosuccinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2) was created. GK-2 activates PI3K/AKT and PLC-γ1 signaling cascades, without affecting MAPK/ERK, and appears to have procognitive properties. In the present study, we investigated the mnemotropic effects of GK-2 with a single intraperitoneal dose of 0.1, 0.5 and 5.0 mg/kg in the novel object recognition test in rats. GK-2 at a dose of 0.5 mg/kg statistically significantly improved the long-term memory of animals. In experiments on the rat hippocampal acute slices, we evaluated the effects of GK-2 on synaptic transmission and its plastic properties in the synaptic system Schaffer collaterals − CA1 pyramidal cell.

关键词

hippocampal slices, PPR, low molecular weight NGF mimetic, novel object recognition test

参考

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