A Decrease in the Cognitive Status of Patients in the Long Term After Ischemic Stroke is Associated with the Levels of Adrenocorticotropic Hormone and Cortisol in the Hair

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Abstract

Post-stroke cognitive impairment (PCN) is a common complication after ischemic stroke (IS). There is evidence that their development is largely due to regulatory and structural changes in neuroendocrine systems involved in the body’s adaptation to stress. Stress-related clinical and biochemical parameters were analyzed in 14 patients with normal cognitive status after AI, in 15 patients with mild cognitive impairment after AI, and in 10 people without stroke of the appropriate age and gender. The indicators were evaluated in the first days, a month later, six months later, and a year after AI. Using the logistic regression method, it was shown that a simultaneous decrease in the level of cortisol in hair and the level of adrenocorticotropic hormone (ACTH) in blood plasma six months after AI predicts a high probability of an unfavorable prognosis for the cognitive status of patients in the long term after a stroke. The data confirm previously obtained results indicating a significant contribution of stress-realizing systems in the development of post-stroke cognitive impairment.

About the authors

T. A Druzhkova

Moscow Research and Clinical Center for Neuropsychiatry

Email: email@example.com
Moscow, Russia

M. Yu Zhanina

Moscow Research and Clinical Center for Neuropsychiatry; Department of Functional Biochemistry of Nervous System, Institute of Higher Nervous Activity and Neurophysiology, RAS

Email: email@example.com
Moscow, Russia; Moscow, Russia

E. E Vladimirova

M.P. Konchalovsky City Clinical Hospital

Email: email@example.com
Moscow, Russia

A. B Guekht

Moscow Research and Clinical Center for Neuropsychiatry; Department of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University

Email: email@example.com
Moscow, Russia; Moscow, Russia

N. V Gulyaeva

Moscow Research and Clinical Center for Neuropsychiatry; Department of Functional Biochemistry of Nervous System, Institute of Higher Nervous Activity and Neurophysiology, RAS

Email: nata_gul@ihna.ru
Moscow, Russia; Moscow, Russia

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