Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences68232510.31857/S0869813924110018VGMTAYREVIEWОБЗОРНЫЕ СТАТЬИReview ArticleNeurosteroid hormone vitamin D: modern prospectsНейростероидный гормон витамин Д: современные горизонты исследованийLebedevA. S.ЛебедевА. С.
Russian Federation

Neurobiology Department, Research Center for Genetics and Life Sciences, Institute of Translational Biomedicine

Направление «Нейробиология», Научный центр генетики и наук о жизни, Институт трансляционной биомедицины

avkalueff@gmail.comShevlyakovA. D.ШевляковА. Д.
Russian Federation

Neurobiology Department, Research Center for Genetics and Life Sciences

Направление «Нейробиология», Научный центр генетики и наук о жизни

avkalueff@gmail.comIlyinN. P.ИльинН. П.
Russian Federation

Institute of Translational Biomedicine

Институт трансляционной биомедицины

avkalueff@gmail.comGalstyanD. S.ГалстянД. С.
Russian Federation

Institute of Translational Biomedicine

Институт трансляционной биомедицины

avkalueff@gmail.comApukhtinK. V.АпухтинК. В.
Russian Federation

Neurobiology Department, Research Center for Genetics and Life Sciences

Направление «Нейробиология», Научный центр генетики и наук о жизни

avkalueff@gmail.comGolushkoN. I.ГолушкоН. И.
Russian Federation

Institute of Translational Biomedicine

Институт трансляционной биомедицины

avkalueff@gmail.comKaluevA. V.КалуевA. В.
Russian Federation

Neurobiology Department, Research Center for Genetics and Life Sciences, Institute of Translational Biomedicine

Направление «Нейробиология», Научный центр генетики и наук о жизни, Институт трансляционной биомедицины

avkalueff@gmail.comAlmazov National Medical Research Center, Ministry of HealthНациональный медицинский исследовательский центр им. В.А. Алмазова МЗ РФSirius University of Science and TechnologyНаучно-технологический университет «Сириус»St. Petersburg State UniversityСанкт-Петербургский государственный университет151120241101103062025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://transsyst.ru/0869-8139/article/view/682325

Vitamin D (calciferol) is a key vitamin, playing an important role in the regulation of the musculoskeletal, immune, cardiovascular and nervous systems. Vitamin D deficiency is a risk factor for multiple brain disorders. Data are also accumulating on the neuroprotective properties of vitamin D, its ability to improve neuronal function and reduce brain disorders. Here, we focus on the latest clinical and preclinical (rodents and zebrafish) data on the role of vitamin D as a neurosteroid hormone, its role in regulating the synthesis and functions of neurotransmitters and neurotrophic factors. A better understanding of the role of vitamin D in brain function may lead to new approaches to the treatment and prevention of vitamin D deficiency-related brain disorders.

Секостероидный гормон витамин Д является важнейшим витамином в организме, регулирующим метаболизм кальция и функционирование костно-мышечной, иммунной и сердечно-сосудистой систем. Витамин Д и его рецепторы также участвуют в регуляции многих процессов в нервной системе, позволяя считать его классическим нейростероидным гормоном. Недостаточность витамина Д ассоциирована с целым рядом заболеваний мозга, многие симптомы которых ослабляются при его введении. В работе рассмотрены клинические и доклинические данные последних лет о роли витамина Д и его рецепторов в функционировании мозга, а также новые перспективы исследований в данной области. Более полное понимание нейробиологии данного нейростероида и механизмов его действия может способствовать созданию новых подходов к лечению и профилактике расстройств мозга, связанных с нарушениями в системе витамина Д.

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