Russian Journal of PhysiologyRussian Journal of PhysiologyРоссийский физиологический журнал им. И.М. Сеченова0869-81392658-655XThe Russian Academy of Sciences65161210.31857/S0869813924070015BEDMRQREVIEWОБЗОРНЫЕ СТАТЬИReview ArticleMolecular-genetic markers of neuroglia in traumatic brain injury and their use for assessing functional status of sportsmenМолекулярно-генетические маркеры нейроглии при черепно-мозговых травмах и их использование для оценки функционального состояния спортсменовCherepanovaА. V.ЧерепановаА. В.
Russian Federation
anesthesia.cher@gmail.comBravyY. R.БравыйЯ. Р.
Russian Federation
anesthesia.cher@gmail.comKarabelskyA. V.КарабельскийА. В.
Russian Federation
anesthesia.cher@gmail.comKotovaМ. M.КотоваМ. М.
Russian Federation
anesthesia.cher@gmail.comSherbakovaA. S.ЩербаковаА. С.
Russian Federation
anesthesia.cher@gmail.comApukhtinК. V.АпухтинК. В.
Russian Federation
anesthesia.cher@gmail.comNikitinV. S.НикитинВ. С.
Russian Federation
anesthesia.cher@gmail.comBobrovМ. Yu.БобровМ. Ю.
Russian Federation
anesthesia.cher@gmail.comKalueffA. V.КалуевA. В.
Russian Federation

Institute of Translational Biomedicine

Институт трансляционной биомедицины

anesthesia.cher@gmail.comSirius University of Science and TechnologyАвтономная некоммерческая образовательная организация высшего образования «Научно–технологический университет «Сириус»Kuban State Agrarian University named after I. T. TrubilinКубанский государственный аграрный университет им. И. Т. ТрубилинаSt. Petersburg State UniversityСанкт-Петербургский государственный университет1507202411071057107401022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://transsyst.ru/0869-8139/article/view/651612

Neuroglia performs multiple important functions including maintaining brain homeostasis, metabolism, neuroprotection and modulating neurotransmission. Studying the role of neuroglia is necessary to understand the development of pathological neurodegenerative processes, as well as the restoration of nervous tissue during inflammation or injury. However, the analysis of neuroglial processes is complicated by its high heterogeneity and the lack of a system of biomarkers that make it possible to unambiguously assess the functional state of the nervous system. Here, we analyze data on clinically significant molecular genetic markers of different types of neuroglia, and the prospects for their use in sport physiology, including the assessment of athletes following traumatic brain injuries of varying severity and other types of sport-related traumas.

Нейроглия выполняет многие важные физиологические функции, включая поддержание гомеостаза и метаболизма клеток мозга, нейропротекцию и модуляцию нейротрансмиссии. Изучение роли нейроглии необходимо для понимания развития патологических нейродегенеративных процессов, а также восстановления нервной ткани при нейровоспалении или травмах мозга, часто отмечающихся в спорте. Однако анализ процессов, происходящих в нейроглиальных клетках, затруднен из-за их высокой гетерогенности и отсутствия системы биомаркеров, позволяющих однозначно оценить функциональное состояние нервной системы в целом. В работе анализируются данные о клинически и биологически значимых молекулярно-генетических маркерах разных типов нейроглии и обсуждаются перспективы их использования в спорте, в том числе для оценки состояния спортсменов на фоне травм мозга различной тяжести и иных видов спортивных травм.

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