Disease detection by volatile organic compound analysis: II. Direct sample injection mass spectrometry


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Abstract

The results of the application of mass spectrometry with direct sample injection in the diagnosis of diseases in humans and laboratory animals are presented. Various methods for obtaining mass spectra of volatile organic compounds (VOCs) are considered, allowing VOCs analysis without using sample concentration and chromatographic separation. This approach, reminiscent of the work of trained sniffing dogs, ensures minimal sample analysis time and high sensitivity, which is extremely important for mass analysis. The authors’ own results on the development of a new method of VOC ionization for the analysis of biological samples are also presented.

About the authors

S. M. Nikiforov

Institute of General Physics of the Russian Academy of Sciences

119991 GSP-1, Moscow, Vavilova St., 38

A. V. Pento

Institute of General Physics of the Russian Academy of Sciences

119991 GSP-1, Moscow, Vavilova St., 38

O. O. Kiryukhina

Federal State Budgetary Institution of Science Institute for Information Transmission Problems named after A.A. Kharkevich RAS

127051, Moscow, Bolshoy Karetniy lane, 19, building 1, Russia

E. I. Rodionova

Federal State Budgetary Institution of Science Institute for Information Transmission Problems named after A.A. Kharkevich RAS

Email: a.rodionova@gmail.com
127051, Moscow, Bolshoy Karetniy lane, 19, building 1, Russia

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