Arylidene-imidazolones with three electron-donating substitutions as fluorogenic dyes for lipid droplets of living cells
- Авторлар: Rudik D.I.1, Gilvanov A.R.1,2, Smirnov A.Y.1,2, Bogdanova Y.A.1,2, Krasnova S.A.1, Baranov M.S.1,2
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Мекемелер:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS
- Pirogov Russian National Research Medical University
- Шығарылым: Том 51, № 1 (2025)
- Беттер: 153-159
- Бөлім: ПИСЬМА РЕДАКТОРУ
- URL: https://transsyst.ru/0132-3423/article/view/683105
- DOI: https://doi.org/10.31857/S0132342325010145
- EDN: https://elibrary.ru/LYIZOX
- ID: 683105
Дәйексөз келтіру
Аннотация
A pair of new fluorogenic dyes from the arylidene-imidazolones’ family, containing simultaneously three electron-donating groups in the arylidene fragment, has been obtained. The optical properties of the resulting compounds were studied. It was shown that they are characterized by a noticeable bathochromic shift of absorption and emission maxima, as well as a pronounced variation of the position of the emission maximum depending on the properties of the environment. Using the HeLa Kyoto and Huh 7.5 cell lines as an example, we demonstrated that (Z)-5-(3,5-bis(dimethylamino)-4-(ethylamino)benzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one can be used as a selective fluorogenic dye for fluorescent labeling of lipid droplets, which indicates the potential of this fluorogen for staining these organelles in other living systems.
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Авторлар туралы
D. Rudik
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS
Хат алмасуға жауапты Автор.
Email: svetlanakr2002@mail.ru
Ресей, Moscow
A. Gilvanov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS; Pirogov Russian National Research Medical University
Email: svetlanakr2002@mail.ru
Ресей, Moscow; Moscow
A. Smirnov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS; Pirogov Russian National Research Medical University
Email: svetlanakr2002@mail.ru
Ресей, Moscow; Moscow
Yu. Bogdanova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS; Pirogov Russian National Research Medical University
Email: svetlanakr2002@mail.ru
Ресей, Moscow; Moscow
S. Krasnova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: svetlanakr2002@mail.ru
Ресей, Moscow
M. Baranov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS; Pirogov Russian National Research Medical University
Email: svetlanakr2002@mail.ru
Ресей, Moscow; Moscow
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