I.P. Pavlov Journal of Higher Nervous ActivityI.P. Pavlov Journal of Higher Nervous ActivityЖурнал высшей нервной деятельности им. И.П. Павлова0044-46773034-5316The Russian Academy of Sciences68089810.31857/S0044467725020021ОБЗОРЫ И ТЕОРЕТИЧЕСКИЕ СТАТЬИReview ArticleNeuronal-glial interactions in learning and behavior under normal conditions and during oncogenesisНейронально-глиальные взаимодействия при научении и поведении в норме и при онкогенезеVenerinaYa. A.ВенеринаЯ. А.
Russian Federation
y.a.venerina@yandex.ruVenerinА. А.ВенеринА. А.
Russian Federation
y.a.venerina@yandex.ruGorkinА. G.ГоркинА. Г.
Russian Federation
y.a.venerina@yandex.ruAlexandrovYu. I.АлександровЮ. И.
Russian Federation
y.a.venerina@yandex.ruSechenov UniversityПервый Московский государственный медицинский университет им. И.М. СеченоваInstitute of Psychology of the Russian Academy of SciencesИнститут психологии Российской академии наук1503202575215316928052025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://transsyst.ru/0044-4677/article/view/680898

The review examines modern studies of glial-neuronal interactions in the formation of new experiences under normal conditions and in the development of pathology in the brain, in particular, tumor growth. According to modern concepts, glial cells play a key role in synaptic plasticity, regulation of neural activity and memory formation. In the oncological process in the brain, the activity of atypical cells affects the interaction of neurons and glia, changing the functional architecture of the brain, which is not always accompanied by loss of function associated with the area of tumor localization. The analyzed data suggest the presence of mutual adaptation of healthy and atypical cells to co-existence, as well as the possibility of changing the metabolism of tumor cells by specializing neurons.

Обзор рассматривает современные исследования глиально-нейрональных взаимодействий при формировании нового опыта в условиях нормы и при развитии патологии в головном мозге, в частности опухолевом росте. Согласно современным представлениям, глиальные клетки играют ключевую роль в синаптической пластичности, регуляции нейронной активности и формировании памяти. При онкологическом процессе в головном мозге активность атипичных клеток влияет на взаимодействие нейронов и глии, изменяя функциональную архитектуру мозга, что не всегда сопровождается утратой функции, ассоциированной с областью локализации опухоли. Проанализированные данные позволяют предположить наличие взаимной адаптации здоровых и атипичных клеток к совместному существованию, а также возможность изменения метаболизма опухолевых клеток путем специализации нейронов.

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