Cell and Tissue BiologyCell and Tissue BiologyЦитология0041-37713034-6061The Russian Academy of Sciences66959010.31857/S0041377124030011PERILRArticlesСтатьиResearch ArticleReception of damage and activation of growth of connective tissue: crucial regulatory milestones of regeneration in humansРецепция повреждения и активация роста соединительной ткани: ключевые регуляторные этапы регенерации у человекаEremichevR. Y.ЕремичевР. Ю.
Russian Federation

Laboratory of gene and cell therapy, Institute for regenerative medicine, Medical research and education centre, Chair of Biochemistry and Regenerative medicine, Faculty of Medicine

Лаборатория генно-клеточной терапии, Институт регенеративной медицины, Медицинский научно-образовательный центр, кафедра биохимии и регенеративной медицины факультета фундаментальной медицины

makarevichpi@my.msu.ruMakarevichP. I.МакаревичП. И.
Russian Federation

Laboratory of gene and cell therapy, Institute for regenerative medicine, Medical research and education centre, Chair of Biochemistry and Regenerative medicine, Faculty of Medicine

Лаборатория генно-клеточной терапии, Институт регенеративной медицины, Медицинский научно-образовательный центр, кафедра биохимии и регенеративной медицины факультета фундаментальной медицины

makarevichpi@my.msu.ruLomonosov Moscow State UniversityМГУ имени М. В. Ломоносова1505202466320722227022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://transsyst.ru/0041-3771/article/view/669590

Tissue damage activates programs aimed at the survival of the body and restoration of its integrity, but for a long time the molecular and cellular mechanisms of their implementation remained undeciphered. In recent years, a number of important information has been obtained about the regulation of regeneration processes, which significantly clarify a number of ideas about the regulation of the response to damage and deserve attention in terms of searching for new targets for controlling this process. This review briefly summarizes the basic regulatory mechanisms associated with the early stages of the human tissue response to injury. It also provides current data on the mechanisms of damage reception and the role of stromal cells in the formation of primary connective tissue as a structure that determines the outcome.

Повреждение тканей активирует программы, направленные на выживание организма и восстановление его целостности, однако длительное время молекулярные и клеточные механизмы их реализации оставались нерасшифрованными. За последние годы получен ряд важных сведений о механизмах регенерации, которые в значительной степени уточняют представления о регуляции ответа на повреждение и заслуживают внимания в плане поиска новых мишеней для управления этим процессом. В данном обзоре кратко суммируются сведения об основных механизмах регуляции, связанных с ранними этапами ответа тканей человека на повреждение. Также приводятся актуальные данные о механизмах рецепции повреждения и роли стромальных клеток в формировании первичной соединительной ткани как структуры, определяющей исход регенерации.

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