Моноциты/макрофаги как один из источников миофибробластов при развитии фиброза тканей: роль некодирующих РНК

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В последние годы все больше внимания уделяется изучению роли эпигенетических механизмов в развитии и прогрессировании иммуновоспалительных заболеваний, сопровождающихся развитием фиброза. В отличие от генетических изменений, сохраняющихся на протяжении всей жизни организма, эпигенетические модификации крайне динамичны и могут отличаться как в разных клеточных популяциях, так и в одной и той же клетке в зависимости от стадии дифференцировки и микроокружения. В обзоре обобщены сведения о потенциальной роли ключевых эпигенетических факторов, в частности некодирующих РНК, в процессе дифференцировки циркулирующих моноцитов костномозгового происхождения в миофибробласты, клеточные медиаторы фиброза. Благодаря высокой пластичности и способности к фенотипической трансформации моноциты и макрофаги являются важнейшими участниками тканевого гомеостаза и играют ключевую роль при развитии фиброза на всех этапах восстановления ткани – от воспаления до ремоделирования.

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О. В. Балан

Институт биологии – обособленное подразделение Карельского научного центра Российской академии наук

Автор, ответственный за переписку.
Email: ovbalan@mail.ru
Россия, Петрозаводск, 185910

И. Е. Малышева

Институт биологии – обособленное подразделение Карельского научного центра Российской академии наук

Email: ovbalan@mail.ru
Россия, Петрозаводск, 185910

О. М. Федоренко

Институт биологии – обособленное подразделение Карельского научного центра Российской академии наук

Email: ovbalan@mail.ru
Россия, Петрозаводск, 185910

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