Russian Journal of GeneticsRussian Journal of GeneticsГенетика0016-67583034-5103The Russian Academy of Sciences66699010.31857/S0016675824020065DQTXKJГЕНЕТИКА ЧЕЛОВЕКАResearch ArticleA study of association of the VNTR MIR-137 rs58335419 with schizophreniaИзучение ассоциации VNTR полиморфизма rs58335419 гена MIR137 с риском развития шизофренииKorovaitsevaG. I.КоровайцеваГ. И.
Russian Federation
korovaitseva@mail.ruOleichikI. V.ОлейчикИ. В.
Russian Federation
korovaitseva@mail.ruLezheikoT. V.ЛежейкоТ. В.
Russian Federation
korovaitseva@mail.ruGolimbetV. E.ГолимбетВ. Е.
Russian Federation
golimbet@mail.ruMental Health Research CentreНаучный центр психического здоровья15022024602636926022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://transsyst.ru/0016-6758/article/view/666990

The MIR137 gene encodes microRNA-137 (miR-137), which is a brain-enriched miR that is highly expressed in various brain regions. miR-137 has been identified as a modulator of processes involved in the pathogenesis of neuropsychiatric disorders. Functional polymorphism of variable number of tandem repeats (VNTR) rs58335419 was found in the regulatory region of the MIR137 gene. It is associated with a change in the expression of miR-137 and, as a result, with an increased risk of developing psychopathologies, including schizophrenia. In this study, we for the first time have analyzed the distribution of frequencies of alleles and genotypes of VNTR MIR137 in a large sample from the Russian population. The association of VNTR with the risk of schizophrenia has been studied. It was found that the presence of VNTR alleles with more than three repeats, as well as a genotype homozygous for such alleles, is associated with an increased risk of developing schizophrenia (OR = 1.4, 95% CI: 1.01-1.95).

Ген MIR137 кодирует микроРНК-137 (miR-137), которая активно экспрессируется в различных областях головного мозга и была идентифицирована как модулятор процессов, участвующих в патогенезе нервно-психических расстройств. В регуляторной области MIR137 обнаружен функциональный полиморфизм вариабельного числа тандемных повторов (VNTR) rs58335419, связанный с изменением экспрессии miR-137 и, как следствие, с увеличением риска развития психопатологий, в том числе и шизофрении. Нами проведен анализ частоты встречаемости аллелей и генотипов VNTR MIR137 на большой выборке этнических русских российской популяции. Изучена ассоциация VNTR с риском развития шизофрении. Обнаружено, что наличие VNTR-аллелей с числом повторов более трех, а также генотипа, гомозиготного по таким аллелям, связано с увеличением риска развития шизофрении (ОШ = 1.4, 95% ДИ: 1.01–1.95).

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