Russian Journal of GeneticsRussian Journal of GeneticsГенетика0016-67583034-5103The Russian Academy of Sciences66695110.31857/S0016675824040071crdrppГЕНЕТИКА ЧЕЛОВЕКАResearch ArticleToll-like receptor gene polymorphisms in a population-based study of HIV and tuberculosis patients from Eastern Europe and Central AsiaПолиморфизм генов Толл-подобных рецепторов в выборке больных ВИЧ-инфекцией и туберкулезом из стран Восточной Европы и Центральной АзииSalamaikinaS. А.СаламайкинаС. А.
Russian Federation

национальный исследовательский университет

salamaykina@cmd.suKorchaginV. I.КорчагинВ. И.
Russian Federation
salamaykina@cmd.suMironovК. О.МироновК. О.
Russian Federation
salamaykina@cmd.suKulabukhovaЕ. I.КулабуховаЕ. И.
Russian Federation
salamaykina@cmd.suZiminaV. N.ЗиминаВ. Н.
Russian Federation
salamaykina@cmd.suKravtchenkoА. V.КравченкоА. В.
Russian Federation
salamaykina@cmd.suCentral Research Institute of Epidemiology Federal service for surveillance on consumer rights protection and human wellbeingЦентральный научно-исследовательский институт эпидемиологии Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человекаMoscow institute of physics and technologyМосковский физико-технический институтPeoplesʹ Friendship University of Russia (RUDN University)Российский университет дружбы народовKemerovo state medical university of the ministry of health of the Russian FederationКемеровский государственный медицнский университет11042024604849326022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://transsyst.ru/0016-6758/article/view/666951

Genetic diversity of human populations is determined by polymorphic variants of immune response genes and can be linked to the variation in responses to infectious agents. This study compared allele and genotype frequencies of polymorphic variants of TLR1, TLR2, TLR4, TLR6 and TLR8 genes between samples from Eastern Europe and Central Asia. We included 680 unrelated individuals from Eastern Slavic (n = 308), Armenian (n = 137), Tajik (n = 138) and Kyrgyz (n = 97) samples of patients with confirmed diagnoses of HIV and tuberculosis. The international 1000 Genomes Project data - samples of Caucasians (EUR) and countries of eastern (EAS) and southern (SAS) Asia – were used for comparison. Despite the lack of genetic diversity and population differences in allele frequencies of the analyzed genes, the samples differed in a number of loci both from each other and from EAS, SAS samples.

Полиморфные варианты генов иммунного ответа могут быть ассоциированы с особенностями реакции организма на инфекционные агенты и вносят вклад в генетическое разнообразие популяций человка. В настоящем исследовании проведен сравнительный анализ частот аллелей и генотипов полиморфных вариантов генов Толл-подобных рецепторов TLR1, TLR2, TLR4, TLR6 и TLR8 в выборках пациентов с ВИЧ и туберкулезом, проживающих на территории стран Восточной Европы и Центральной Азии. В исследование включено 680 неродственных индивидов из восточнославянской (n = 308), армянской (n = 137), таджикской (n = 138) и киргизской (n = 97) выборок пациентов с установленными диагнозами ВИЧ и туберкулез. Для сравнения использованы данные международного проекта 1000 Genomes – выборки европеоидов (EUR) и представителей стран Восточной (EAS) и Южной (SAS) Азии. Обнаружено, что, несмотря на низкий уровень генетического разнообразия и межпопуляционных различий по частотам аллелей анализируемых генов, исследуемые выборки тем не менее различались по ряду локусов между собой и отличались как от популяций европеоидов, так и от жителей стран Восточной и Южной Азии.

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