Russian Journal of GeneticsRussian Journal of GeneticsГенетика0016-67583034-5103The Russian Academy of Sciences66689810.31857/S0016675823020029KWXQKFКРАТКИЕ СООБЩЕНИЯКРАТКИЕ СООБЩЕНИЯThe CRP Gene’s Role in the Relations between Childhood Adversity and History of Suicide Attempts in SchizophreniaРоль гена CRP во влиянии невзгод детства на риск суицидальных попыток у больных с расстройствами шизофренического спектраAlfimovaM. V.АлфимоваМ. В.m.alfimova@gmail.comLezheikoT. V.ЛежейкоТ. В.m.alfimova@gmail.comGabaevaM. V.ГабаеваМ. В.m.alfimova@gmail.comPlakunovaV. V.ПлакуноваВ. В.m.alfimova@gmail.comMikhailovaV. A.МихайловаВ. А.m.alfimova@gmail.comKaledaV. G.КаледаВ. Г.m.alfimova@gmail.comGolimbetV. E.ГолимбетВ. Е.m.alfimova@gmail.comMental Health Research CenterНаучный центр психического здоровья0102202359223824326022025Copyright ©; 2023, М.В. Алфимова, Т.В. Лежейко, М.В. Габаева, В.В. Плакунова, В.А. Михайлова, В.Г. Каледа, В.Е. ГолимбетCopyright ©; 2023, М.В. Алфимова, Т.В. Лежейко, М.В. Габаева, В.В. Плакунова, В.А. Михайлова, В.Г. Каледа, В.Е. Голимбет2023М.В. Алфимова, Т.В. Лежейко, М.В. Габаева, В.В. Плакунова, В.А. Михайлова, В.Г. Каледа, В.Е. ГолимбетМ.В. Алфимова, Т.В. Лежейко, М.В. Габаева, В.В. Плакунова, В.А. Михайлова, В.Г. Каледа, В.Е. Голимбетhttps://transsyst.ru/0016-6758/article/view/666898

Research suggests that, in contrast to circulating C-reactive protein (CRP), genetic variants conferring higher CRP levels have protective effects against schizophrenia and moderate influences of season of birth on the development of the disease. This study aimed to explore whether the CRP gene also moderates the relations between childhood adversity and clinical characteristics of schizophrenia. The relations between childhood adversity, genotypes at rs2794521within the CRP locus, syndromes measured as five factors and two negative subfactors of the Positive and Negative Syndrome Scale, and history of suicide attempts were analyzed in 921 schizophrenia patients using analyses of covariances, Pearson’s chi-squared test, and logistic regression. A significant effect of genotype on suicide attempts in patients exposed to childhood adversity was found. The result suggests a moderating role of genetic determinants of inflammation in translating early life psychological stress effects into risk of suicide attempts in schizophrenia.

Исследования показывают, что, в отличие от циркулирующего С-реактивного белка (СРБ), генетические варианты, обеспечивающие более высокие уровни СРБ, обладают защитным действием против шизофрении и модифицируют влияние сезона рождения на развитие заболевания. Целью данной работы было установить, влияет ли ген CRP также на связь между невзгодами детства и клиническими характеристиками шизофрении. У 921 больного шизофренией были проанализированы взаимосвязи между неблагополучием в детстве, генотипами в сайте rs2794521 в локусе CRP, синдромами, измеряемыми с помощью 5-факторной модели Шкалы позитивных и негативных синдромов с встроенной 2-факторной моделью негативного синдрома, и историей суицидальных попыток. Обнаружено значимое влияние генотипа на суицидальные попытки у пациентов с невзгодами детства. Результат свидетельствует в пользу модифицирующей роли генетических детерминант воспаления в каскаде событий, опосредующих эффекты пережитого в раннем возрасте психологического стресса на последующий риск суицидальных попыток.

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