Coevolution of Thermoreceptor Genes of the TRP Family in 15 Populations of the Altai-Sayan Region, Western Siberia and the Far East

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Abstract

The analysis of the TRPV3 thermoreceptor gene (rs322937) was carried out in 15 population samples (1503 people) belonging to different language groups living in the regions of the Altai-Sayan Highlands, Western Siberia, the Far East and Canada. The highest frequency of the rare allele was found in the Yakuts (42.9%), and the lowest in the Eskimos (10.7%) and Evenks (10.8%). Deviations from the Hardy-Weinberg equilibrium were found in the population of Siberian Tatars. The greatest interpopulation differences were found between the Yakuts and Evenks, and the smallest between the Kazakhs, Telengits and Khakass, Telengits and Tatars, Khakass and Nanai, Tuvans and Northern Altaians. Transassociation of polymorphic loci of the TRPV1, TRPA1, TRPM8 and TRPV3 genes was carried out using the regression analysis method. Of the six pairs, a positive correlation was found in 3: TRPA1/TRPV3, TRPV3/TRPV1 and TRPV1/TRPM8. Thus, the TRPV3 gene studied by us is positively correlated with TRPV1 and TRPA1 and negatively with TRPM8. The results obtained may indicate different selective pressure in different geographical areas determined by climatic factors.

About the authors

M. A Gubina

Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences

Email: marina@bionet.nsc.ru
Novosibirsk, Russia

V. N Babenko

Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences

Novosibirsk, Russia

A. Yu Gubina

Novosibirsk State Medical University

Novosibirsk, Russia

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